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Practice Guideline Recommendations: Disease-modifying Therapies for Adults with Multiple Sclerosis

Guideline, April 2018

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This article presents the recommendations and suggestions for future research of an American Academy of Neurology (AAN) practice guideline on the efficacy and safety of disease-modifying therapies (DMTs) in multiple sclerosis (MS).

Reaffirmed on September 18, 2021.

Recommendations from current practice guideline. Companion to "Systematic Review: Disease-modifying Therapies for Adults with Multiple Sclerosis" (April 2018). 

Endorsed by the Consortium of Multiple Sclerosis Centers, the Multiple Sclerosis Association of America, and the National Multiple Sclerosis Society. 

Clinician Tools and Materials

Clinician Summary

Download a PDF summary of this guideline product

Companion Publication - Commentary

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Companion Publication - Identifying Priority Outcomes

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Companion Publication - Complexity of MS Management

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Full-length Version

Download a PDF of the full guideline product, including full details of the methodology and data analysis

Patient Tools and Materials

Patient Summary - Starting DMTs for MS

Read a summary of the key messages of this guideline product for patients and care partners.

Patient Summary - Switching DMTs for MS

Read a summary of the key messages of this guideline product for patients and care partners.

Patient Summary - Stopping DMTs for MS

Read a summary of the key messages of this guideline product for patients and care partners.

Press Release

Download the AAN press release about this guideline product

Video for Patients

Patient Summary Translation

Translated in Spanish (Español)

Patient Summary Translation

Translated in Spanish (Español)

Patient Summary Translation

Translated in Spanish (Español)

Questions?

Email guidelines@aan.com

Call (800) 879-1960 or (612) 928-6000 (international)