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Update: Efficacy and Tolerability of the New Antiepileptic Drugs II: Treatment-resistant Epilepsy

Practice Guideline, June 2018

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Since the 2004 publications, the US Food and Drug Administration (FDA) approved 6 new third-generation AEDs and 2 older AEDs. This update reviews new evidence for efficacy of these AEDs in managing treatment-resistant (TR) focal epilepsies and generalized epilepsies (GEs) in children and adults.

Reaffirmed on September 18, 2021.

Codeveloped with the American Epilepsy Society.

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