Abstract Details

Title Is There an Increased Risk of Developing Dementia in Patients with Essential Tremor?

Topic Movement Disorders

Presentation(s) S35 - Movement Disorders: Hyperkinetic Movement Disorders (3:42 PM-3:54 PM)

Poster/Presentation
Number 002

Background Essential tremor is a progressive neurological condition with motor dysfunction that contributes to reduced quality of life. Prior population studies noted increased risk for developing dementia in those with ET. In contrast, a prior study by our group demonstrated no increased risk for dementia in those with ET. The aim of this study is to longitudinally assess a larger cohort of ET and control subjects to compare the risk of developing dementia.

Objective To determine if there is an increased risk of developing dementia in those with essential tremor (ET) compared to controls.

Design/Methods Subjects without dementia or other neurodegenerative disorders were selected from the Arizona Study of Aging and Neurodegenerative Disorders database. The ET group was divided into prevalent ET (ET diagnosis at study entry) and incident ET (ET developed during follow-up). There were 112 subjects with prevalent ET, 111 with incident ET, and 601 controls who were followed over a 10-year period. Subjects underwent annual movement disorders and neuropsychological evaluations. Baseline characteristics of the groups were compared using ANOVA F-test or chi-square test. The cumulative incidence of dementia was compared using Kaplan-Meier curves and a multivariate Cox-regression model.

Results Baseline group characteristics demonstrated older age in incident (81.5±6.7) and prevalent ET (79.6±6) compared to control (76.3±8.3) (p<0.001). Multivariate cox-regression assessing risk for developing dementia showed no significant difference between incident or prevalent ET vs control, or ET symptom onset duration. There was an increased risk for developing dementia with advancing age (hazard ratio 1.11, p < .001), presence of mild cognitive impairment at time of study entry (HR 6.98, p < .001) and male gender (HR 1.83, p = 0.004).

Conclusions There was no increased risk of dementia in those with both prevalent or incident ET within our 10 year study period.

Authors/Disclosures
Emma Sherfinski, MD (Mayo Clinic Hospital) PRESENTER	Ms. Sherfinski has nothing to disclose.
Kartik Mangipudi, MD (Mayo Clinic Arizona)	Dr. Mangipudi has nothing to disclose.
Nan Zhang	No disclosure on file
Charles H. Adler, MD, PhD, FAAN (Mayo Clinic Arizona)	Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avion. Dr. Adler has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CND Life Sci. Dr. Adler has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Jazz. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Precon. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. The institution of Dr. Adler has received research support from NIH. The institution of Dr. Adler has received research support from Michael J. Fox Foundation. The institution of Dr. Adler has received research support from Arizona Biomedical Research Commission. Dr. Adler has received publishing royalties from a publication relating to health care.
Holly A. Shill, MD, FAAN (Barrow Neurology Clinics)	Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sage Biogen. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for KeifeRx. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Praxis Precision Medicine. Dr. Shill has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Fasikl Inc.
Christine Belden	No disclosure on file
Alireza Atri, MD, PhD (Banner Sun Health Research Institute)	Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Prothena. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eisai. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novo Nordisk. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novo Nordisk. Dr. Atri has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche/Genentech. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lunbeck. The institution of Dr. Atri has received research support from National Institute of Aging (NIA). The institution of Dr. Atri has received research support from AZ Department of Health Services. The institution of Dr. Atri has received research support from Gates Ventures. The institution of Dr. Atri has received research support from Multiple companies, universities & consortia for contracted clinical trials to institution. The institution of Dr. Atri has received research support from Washington University in St. Louis. The institution of Dr. Atri has received research support from Foundation for NIH. The institution of Dr. Atri has received research support from ACTC/NIH. Dr. Atri has received publishing royalties from a publication relating to health care.
Thomas Beach (Banner Sun Health Research Institute)	Thomas Beach has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vivid Genomics. Thomas Beach has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche Diagnostics. The institution of Thomas Beach has received research support from National Institutes of Health. The institution of Thomas Beach has received research support from Michael J Fox Foundation . The institution of Thomas Beach has received research support from State of Arizona.
Erika Driver-Dunckley, MD, FAAN	Dr. Driver-Dunckley has nothing to disclose.
Shyamal Mehta, MD, PhD, FAAN (Mayo Clinic, Arizona)	Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Adamas Pharma. Dr. Mehta has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbott. Dr. Mehta has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CNS Ratings.