This study was performed on 2 sub-human primates (Macaca Mulata). Two intracerebral canulas were implanted in the motor part of the striatum of each primate. NaCl- was delivered during control condition and Oxotremorin- M (Tocris Bioscience, UK), a non specific cholinergic agonist was used to induce dystonia. Canulas were connected to programmed micropumps (iPRECIO® SMP-200) for chronic infusion. Dystonic symptoms were evaluated using a modified version of the BFM scale. Recordings were conducted using high impedance tungsten microelectrodes (Alpha Omega, Israël) and targeted the striatum and pallidal regions during control condition (NaCl- infusion) and Oxotremorin infusion. Sampling frequency was 20KHz. Firing rate, CV ISI and autocorrelation were measured for each well isolated unit. Power spectral density of LFP and Multi-unit-activity were computed with Welch's method (3s window, 50% overlap, spectral resolution of 1/3 Hz). FR, CV ISI and LFP power were compared using non parametric Mann & Whitney test.