Abstract Details

Title Greater 5-year Gray Matter Atrophy Is Associated with Newly Arising Paramagnetic Rim Lesions, but Not Disappearing or Persisting Rim Lesions

Topic Multiple Sclerosis

Presentation(s) S42 - Multiple Sclerosis: Biomarkers/Neuroimaging (2:00 PM-2:12 PM)

Poster/Presentation
Number 006

Background

Previous studies have associated PRLs with increased brain atrophy in people with multiple sclerosis (pwMS), supporting the role of PRLs in MS progression. However, it remains unclear if PRLs maintain an association with long-term atrophy throughout their existence or only during specific phases, such as their initial appearance.

Objective

To investigate the associations between newly appearing, disappearing, and persisting paramagnetic rim lesions (PRLs) and longitudinal brain atrophy.

Design/Methods Clinical data and 3T MRI were acquired from 103 pwMS at baseline and 5-year follow-up. PRLs were identified on quantitative susceptibility maps and classified into three groups: “persisting” (present at both baseline and follow-up), “disappearing” (present at baseline but not at follow-up), and “newly appearing” (emerging at follow-up). Linear models were used to test associations between PRLs and percent brain volume changes. All analyses controlled for baseline volume, baseline age, sex, baseline disease duration, baseline MS disease course, time to follow-up, baseline total T2 lesion volume, and change in total T2 lesion volume.

Results At baseline, the average age was 47.7 ± 11.6 years, mean disease duration of 13.7 ± 10.4 years, and median expanded disability status scale was 2.5 (interquartile range 1.5 – 4.5). The mean follow-up time was 5.3 ± 0.5 years. On average, pwMS had 1.7 ± 3.1 PRLs, with 45.6% (47/103) having ≥ 1 PRL. 13.7% (14/103) of pwMS had at least one newly appearing PRL and 17.5% (18/103) had a disappearing PRL. The presence of at least one newly appearing PRL was associated with volume decreases in the whole brain, whole deep gray matter, thalamus, accumbens, pallidum, and putamen, along with an increase in lateral ventricular volume (p < 0.028 for all). No significant associations were seen with disappearing or persisting PRLs.

Conclusions PRLs are linked to longitudinal brain atrophy primarily in the early stages of their existence.

Authors/Disclosures
Jack Reeves PRESENTER	Mr. Reeves has nothing to disclose.
Dejan Jakimovski, MD, PhD (Buffalo Neuroimaging Analysis Center, University at Buffalo)	Dr. Jakimovski has nothing to disclose.
Niels Bergsland (Buffalo Neuroimaging Analysis Center / State University of New York At Buffalo)	Prof. Bergsland has nothing to disclose.
Maryam Mohebbi	No disclosure on file
Fahad Salman	No disclosure on file
Ferdinand Schweser, PhD (SUNY University At Buffalo)	Dr. Schweser has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier.
Bianca Weinstock-Guttman, MD (Department of Neurology, University At Buffalo)	Dr. Weinstock-Guttman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genzyme &Sanofi. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH.
Michael G. Dwyer III, MD, PhD (Buffalo Neurological Analysis Center)	Dr. Dwyer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Keystone Heart, Ltd. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. The institution of Dr. Dwyer has received research support from Novartis. The institution of Dr. Dwyer has received research support from Keystone Heart, Ltd. The institution of Dr. Dwyer has received research support from Bristol Myers Squibb. The institution of Dr. Dwyer has received research support from Roche.
Robert Zivadinov, MD, PhD, FAAN (Buffalo Neuroimaging Analysis Center)	The institution of Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for BMS. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Filterlex. Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for 3D Communications. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Omnicuris. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurology Live. The institution of Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EMD Serono. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Sanofi. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for EMD Serono. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Bristol Myers Squibb. The institution of Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen.