2022 Annual Meeting Virtual Experience | N1 - Neuroscience in the Clinic: Aducanumab: From Clinical Trials to the Clinic

Date Monday 04/25/22

Time 02:30 PM - 05:00 PM EDT Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Neuroscience in the Clinic Session

Director(s) Amy Brodtmann, MBBS, PhD, FRACP, Vijay K. Ramanan, MD, PhD

Topic(s) Aging, Dementia, and Behavioral Neurology

Learning Objectives Knowledge: Participants will be introduced to controversies in aducanumab approval, the landscape of potential disease modifying drugs in dementia, existing trial data, and indications for potential use.
Comprehension: Participants will be presented with evidence for and against aducanumab, including information on amyloid related imaging abnormalities
Application: Illustrate risks and benefits of aducanumab and introduce other monoclonal antibodies and potential disease modifying drugs.
Analysis: Participants will be given tools to appraise evidence for aducanumab approval and provide critical interpretation of trial data.
Synthesis: The panel will assemble opinions from dementia leaders in order to formulate plans for future dementia disease modifying therapies.
Evaluation: Participants will be able to argue the case for and against aducanumab use and be provided with tools for clinical guidance.

CME Available 2.50 CME credits

Core Competencies Patient Care & Procedural Skills, Medical Knowledge, Systems-based Practice

Program Level Intermediate

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Advanced Practice Provider, Medical Student

Teaching Styles Case-based, Audience Participation

Program Materials Program Evaluations

Event Timeline
02:30 PM - 02:40 PM EDT	Speaker	A Disease-modifying Therapy for Dementia? Case vignettes for consideration Amy Brodtmann, MBBS, PhD, FRACP
02:40 PM - 03:10 PM EDT	Speaker	Aducanumab: From Clinical Trial Data to Patient-Centered Use Gil D. Rabinovici, MD, FAAN
03:10 PM - 03:20 PM EDT	Speaker	Defining a Standardized MRI Acquisition Protocol to Be Proposed to ICARE AD Sites for ARIA Monitoring Tammie Benzinger
03:10 PM - 03:20 PM EDT	Abstract	001 - Defining a Standardized MRI Acquisition Protocol to Be Proposed to ICARE AD Sites for ARIA Monitoring Tammie Benzinger
03:20 PM - 03:30 PM EDT	Speaker	Baseline EMBARK Data From EMERGE, ENGAGE, and PRIME Participants in the EMBARK Redosing Study Sharon Cohen, MD
03:20 PM - 03:30 PM EDT	Abstract	002 - Baseline EMBARK Data From EMERGE, ENGAGE, and PRIME Participants in the EMBARK Redosing Study Sharon Cohen, MD
03:30 PM - 03:50 PM EDT	Speaker	Workflow Implications for Aducanumab in Clinical Practice Vijay K. Ramanan, MD, PhD
03:50 PM - 05:00 PM EDT	Q&A	Live Q&A Amy Brodtmann, MBBS, PhD, FRACP, Vijay K. Ramanan, MD, PhD, Gil D. Rabinovici, MD, FAAN, Sharon Cohen, MD, Tammie Benzinger

Faculty Disclosures
Amy Brodtmann, MBBS, PhD, FRACP	Prof. Brodtmann has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Prof. Brodtmann has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Prof. Brodtmann has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. The institution of Prof. Brodtmann has received research support from National Health and Medical Research Council. The institution of Prof. Brodtmann has received research support from Medical Research Future Fund. The institution of Prof. Brodtmann has received research support from National Heart Foundation. The institution of Prof. Brodtmann has received research support from Victorian Medical Research Acceleration Fund. Prof. Brodtmann has a non-compensated relationship as a Honorary Medical Advisor with Dementia Australia that is relevant to AAN interests or activities.
Vijay K. Ramanan, MD, PhD	The institution of Dr. Ramanan has received research support from the National Institutes of Health. The institution of Dr. Ramanan has received research support from the Mangurian Foundation for Lewy Body Disease Research. The institution of Dr. Ramanan has received research support from as part of clinical trials sponsored by the Alzheimer's Association, Eisai, the Alzheimer's Treatment and Research Institute at USC, and Transposon Therapeutics, Inc.. The institution of Dr. Ramanan has received research support from Medscape. Dr. Ramanan has received personal compensation in the range of $500-$4,999 for serving as a Conference Speaker/Organizer (Honoraria) with AANI.
Gil D. Rabinovici, MD, FAAN	Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alector. Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Johnson & Joihnson. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Rabinovici has received research support from NIH. The institution of Dr. Rabinovici has received research support from American College of Radiology. The institution of Dr. Rabinovici has received research support from Alzheimer's Association. The institution of Dr. Rabinovici has received research support from Rainwater Charitable Foundation. The institution of Dr. Rabinovici has received research support from Genentech. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Topic Chair, Course Director and teacher with AAN. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Invited speaker with ANA.
Frederik Barkhof, MD, PhD	Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Frederik Barkhof has received personal compensation in the range of $0-$499 for serving as a Consultant for Biogen. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Combinostics. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for IXICO. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Frederik Barkhof has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EISAI.
Elizabeth Fisher	Elizabeth Fisher has received personal compensation for serving as an employee of Biogen. Elizabeth Fisher has stock in Biogen. Elizabeth Fisher has received intellectual property interests from a discovery or technology relating to health care.
Christopher T. Whitlow, MD	Dr. Whitlow has nothing to disclose.
Tammie Benzinger	Tammie Benzinger has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Tammie Benzinger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Tammie Benzinger has received personal compensation in the range of $0-$499 for serving as a Consultant for Sora Neuroscience. Tammie Benzinger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Tammie Benzinger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai. Tammie Benzinger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Tammie Benzinger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Johnson & Johnson. Tammie Benzinger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol, Myers Squibb. Tammie Benzinger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for PeerView. Tammie Benzinger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Medscape. The institution of Tammie Benzinger has received research support from Siemens. The institution of Tammie Benzinger has received research support from Hyperfine. Tammie Benzinger has a non-compensated relationship as a Consultant with Siemens that is relevant to AAN interests or activities. Tammie Benzinger has a non-compensated relationship as a Consultant with Eisai that is relevant to AAN interests or activities.
Alex Rovira	Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofy. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Biogen. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers. Alex Rovira has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer. Alex Rovira has stock in Tensor Medical.
	No disclosure on file
Sharon Cohen, MD	The institution of Dr. Cohen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alnylam. The institution of Dr. Cohen has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. The institution of Dr. Cohen has received personal compensation in the range of $0-$499 for serving as a Consultant for Diamond Therapeutics Inc.. The institution of Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. The institution of Dr. Cohen has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for ProMIS Neurosciences Inc.. The institution of Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for RetiSpec Inc.. The institution of Dr. Cohen has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for College of Physicians and Surgeons of Ontario. The institution of Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for CME Outfitters. The institution of Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Integritas. The institution of Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for DBK Med.
Anton P. Porsteinsson, MD	Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ONO Pharmaceuticals. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Porsteinsson has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for IQVIA. Dr. Porsteinsson has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for WebMD. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lundbeck. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Otsuka. Dr. Porsteinsson has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acadia. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Functional Neuromodulation. Dr. Porsteinsson has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Xenon Pharmaceuticals. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Porsteinsson has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cognitive Research Corporation. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Athira. Dr. Porsteinsson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BMS. The institution of Dr. Porsteinsson has received research support from Alector. The institution of Dr. Porsteinsson has received research support from Eisai. The institution of Dr. Porsteinsson has received research support from Eli Lilly. The institution of Dr. Porsteinsson has received research support from Athira. The institution of Dr. Porsteinsson has received research support from Genentech/Roche. The institution of Dr. Porsteinsson has received research support from Cassava. The institution of Dr. Porsteinsson has received research support from Vaccinex.
Stephen P. Salloway, MD, MS	Dr. Salloway has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EISAI. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Lilly. Dr. Salloway has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for NovoNordisk. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Prothena. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amylyx. Dr. Salloway has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bolden. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for EISAI. Dr. Salloway has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Acumen. Dr. Salloway has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly.
Samantha Budd Haeberlein	Samantha Budd Haeberlein has received personal compensation for serving as an employee of Biogen. An immediate family member of Samantha Budd Haeberlein has received personal compensation for serving as an employee of Alkermes. Samantha Budd Haeberlein has received stock or an ownership interest from Biogen.
Annie Racine, PhD	Annie Racine has received personal compensation for serving as an employee of Biogen. Annie Racine has received stock or an ownership interest from Biogen.
Christopher van Dyck, MD	Christopher van Dyck, MD has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Christopher van Dyck, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono. Christopher van Dyck, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevel. Christopher van Dyck, MD has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eisai. An immediate family member of Christopher van Dyck, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Supurnus. An immediate family member of Christopher van Dyck, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Polaris Management Partners. The institution of Christopher van Dyck, MD has received research support from Roche/Genentech. The institution of Christopher van Dyck, MD has received research support from Eli Lilly. The institution of Christopher van Dyck, MD has received research support from Biogen. The institution of Christopher van Dyck, MD has received research support from Biohaven. The institution of Christopher van Dyck, MD has received research support from Eisai. The institution of Christopher van Dyck, MD has received research support from UCB. The institution of Christopher van Dyck, MD has received research support from Cerevel. The institution of Christopher van Dyck, MD has received research support from Janssen.