2018 Annual Meeting | S5 - General Neurology: Advances in Neurotherapeutics

Date Sunday 04/22/18

Time 01:00 PM - 03:00 PM Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program is not expected to be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Topic(s) General Neurology

CME Available 2.00 CME credits

Event Timeline
01:00 PM - 03:00 PM	Abstract	001 - Characterization of Atxn2 in ALS Patient Samples and Insight into ASO Therapy Amy Taylor
01:00 PM - 03:00 PM	Abstract	002 - Quantitative Determination of SMN2 Copy Number using Next Generation Sequencing and Correlation to Disease Severity Jody Westbrook
01:00 PM - 03:00 PM	Abstract	003 - Effects of Elamipretide in Adults with Primary Mitochondrial Myopathy: a Phase 2 Double-Blind, Randomized, Placebo-Controlled Crossover Trial (MMPOWER-2) Bruce H. Cohen, MD, FAAN
01:00 PM - 03:00 PM	Abstract	004 - Modulation of Transcriptomic Changes in Alzheimer Disease by Ethnicity
01:00 PM - 03:00 PM	Abstract	005 - Canagliflozin Associated with MELAS Pseudoexacerbation Ramita Dewan
01:00 PM - 03:00 PM	Abstract	006 - Inotersen Improves Norfolk Quality of Life-Diabetic Neuropathy Measures in Patients With Hereditary Transthyretin Amyloidosis with Polyneuropathy in the Phase 3 Study NEURO-TTR Michael J. Polydefkis, MD, FAAN
01:00 PM - 03:00 PM	Abstract	007 - Variation of Penetrance estimates in a wide spectrum of TTR-FAP families: implication for management of carriers Farida Gorram
01:00 PM - 03:00 PM	Abstract	008 - Glycemic Control Boosts Glucosylated Nanocarrier Crossing the BBB into the Brain Hiroya Kuwahara, MD, PhD
02:35 PM - 03:00 PM	Discussion	Discussion

Faculty Disclosures
Pravin Khemani, MD, FAAN	Dr. Khemani has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boston Scientific. Dr. Khemani has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Cala Trio. Dr. Khemani has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Neurocrine.
Lucas Restrepo, MD, PhD	Dr. Restrepo has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Eisai. Dr. Restrepo has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Lilly USA. Dr. Restrepo has received personal compensation in the range of $1,000,000+ for serving as an officer or member of the Board of Directors for Kelvi/Hypothermia Devices, Inc.. Dr. Restrepo has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for SAGE Journals, The Neurohospitalist. Dr. Restrepo has stock in Hypothermia Devices, Inc. (dba Kelvi). Dr. Restrepo has stock in Eli Lilly. Dr. Restrepo has received intellectual property interests from a discovery or technology relating to health care.
Thomas Brannagan III, MD, FAAN	Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pfizer. Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Grifols. Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for CSL. Dr. Brannagan has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alnylam. The institution of Dr. Brannagan has received research support from Alnylam. The institution of Dr. Brannagan has received research support from Acceleron. The institution of Dr. Brannagan has received research support from Ionis. The institution of Dr. Brannagan has received research support from Pharnext.
	No disclosure on file
Takanori Yokota, MD, PhD	Dr. Yokota has nothing to disclose.
Bruce H. Cohen, MD, FAAN	Dr. Cohen has received personal compensation in the range of $0-$499 for serving as a Consultant for CoA Therapeutics/BioBridge. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abliva/NeuroVive. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Modis/Zogenix/USB. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PTC Pharmaceuticals. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Precision BioSciences . Dr. Cohen has received personal compensation in the range of $0-$499 for serving as a Consultant for Pretzel. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Stealth Bio. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Allergan. The institution of Dr. Cohen has received research support from Stealth Biotherapeutics. The institution of Dr. Cohen has received research support from BioElectron Technologies/PTC. The institution of Dr. Cohen has received research support from Astellas/MitoBridge. The institution of Dr. Cohen has received research support from Reneo Pharmaceuticals. The institution of Dr. Cohen has received research support from Abliva. The institution of Dr. Cohen has received research support from Tisento. Dr. Cohen has received publishing royalties from a publication relating to health care. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a Consultant with US DOJ. Dr. Cohen has received personal compensation in the range of $500-$4,999 for serving as a CPT Advisor with AAN. Dr. Cohen has a non-compensated relationship as a Officer with Child Neurology Society that is relevant to AAN interests or activities. Dr. Cohen has a non-compensated relationship as a Officer with Child Neurology Foundation that is relevant to AAN interests or activities.
John M. Ravits, MD, FAAN	Dr. Ravits has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Iris, Inc. Dr. Ravits has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Maze, Inc. Dr. Ravits has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Transposon, Inc. Dr. Ravits has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Libra, Inc. The institution of Dr. Ravits has received research support from NIH R21 Research Grant. The institution of Dr. Ravits has received research support from NIH R01 Research Grant. The institution of Dr. Ravits has received research support from FightMND Foundation Research Grant. The institution of Dr. Ravits has received research support from DOD Research Grant. Dr. Ravits has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH Office of Scientific Review.
Richard H. Haas, MD	No disclosure on file
Hiroya Kuwahara, MD, PhD	Dr. Kuwahara has nothing to disclose.
Jody Westbrook	Jody Westbrook has received personal compensation for serving as an employee of Invitae. Jody Westbrook has received stock or an ownership interest from Invitae.
Peter J. Dyck, MD, FAAN	Dr. Dyck has nothing to disclose.
Brenda F. Baker	No disclosure on file
Annabel K. Wang, MD, FAAN	Dr. Wang has nothing to disclose.
Sandra Diaz Garcia, PhD	No disclosure on file
Amy Goldstein, MD	No disclosure on file
Amy Taylor	No disclosure on file
Ramita Dewan	No disclosure on file
Brett Monia, PhD	No disclosure on file
Olivia Gardner, MD, PhD	No disclosure on file
Merrill Benson	No disclosure on file
Margaret A. Pericak-Vance, PhD	Dr. Pericak-Vance has nothing to disclose.
Ole Suhr	The institution of Ole Suhr has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam . The institution of Ole Suhr has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Akcea. The institution of Ole Suhr has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Prothena. The institution of Ole Suhr has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Intellia. The institution of Ole Suhr has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Akces. The institution of Ole Suhr has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alnylam. Ole Suhr has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Alnylam. Ole Suhr has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Akcea. The institution of Ole Suhr has received research support from Swedish Heart and Lung Foundation.
Bradley W. McEvoy	Bradley W. McEvoy has received personal compensation for serving as an employee of Acadia Pharmaceuticals. Bradley W. McEvoy has received stock or an ownership interest from Acadia Pharmaceuticals.
John Cole, MD	Dr. Cole has nothing to disclose.
Josep Gamez, MD, PhD	The institution of Dr. Gamez has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for CSL Behring. The institution of Dr. Gamez has received research support from Government of Spain (FIS FEDER).
Christopher Stack, MD	No disclosure on file
Teresa Coelho, MD	Dr. Coelho has nothing to disclose.
Acary S. Oliveira, MD	No disclosure on file
Farida Gorram	No disclosure on file
Michael J. Polydefkis, MD, FAAN	Dr. Polydefkis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam Pharmaceuticals. Dr. Polydefkis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Akcea. Dr. Polydefkis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vertex Pharmaceutical . Dr. Polydefkis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen-Idec. Dr. Polydefkis has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer.
Fabio Adrian Barroso, MD	Fabio Adrian Barroso, MD has nothing to disclose.
Isabel Conceicao	Isabel Conceicao has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam. Isabel Conceicao has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sobi.
Perry Shieh, MD, PhD, FAAN	Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Sarepta. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Genentech. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Argenx. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for UCB. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for CSL Behring. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Grifols. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Alexion. Dr. Shieh has received personal compensation in the range of $50,000-$99,999 for serving on a Speakers Bureau for Biogen. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Genentech. Dr. Shieh has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Argenx. Dr. Shieh has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Catalyst.
Steven hughes	No disclosure on file
David D. Adams	David D. Adams has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for ALNYLAM. David D. Adams has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pfizer.
Thomas L. Winder, PhD, FACMG	Dr. Winder has nothing to disclose.
Gary W. Beecham, PhD	The institution of Dr. Beecham has received research support from NIH. The institution of an immediate family member of Dr. Beecham has received research support from NIH.
Elizabeth Ackermann, PhD	No disclosure on file
Violaine Plante-Bordeneuve, MD	Dr. Plante-Bordeneuve has nothing to disclose.
John L. Berk	John L. Berk has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam Pharmaceuticals. John L. Berk has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ionis Pharmaceuticals. John L. Berk has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Astra Zeneca/IONIS. John L. Berk has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eidos/BridgBio. John L. Berk has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Intellia Therapeutics. John L. Berk has received research support from Alnylam . John L. Berk has received research support from Ionis. John L. Berk has received research support from Eidos/Bridgbio.
Jonathan Haines, MD	No disclosure on file
Marcia Waddington Cruz, MD	Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pfizer. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ionis. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Astra Zeneca. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for PTC. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alnylam. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sobi. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Pfizer. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ionis. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for PTC. Dr. Waddington Cruz has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NovoNordisk.