About Guidelines

Guidelines

Clinical practice guidelines are statements that include recommendations intended to optimize patient care. They are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options.

Learn about the Guideline Development Process

AAN clinical practice guidelines are developed using a rigorous process rooted in evidence-based medicine methodology. The current guideline development process is described in the latest edition of the AAN Clinical Practice Guideline Process Manual, which was approved by the AAN Institute Board of Directors in 2017.

Read the Guideline Process Manual

2017 process manual amendments

PREVIOUS GUIDELINE DEVELOPMENT MANUALS

Access previous AAN development process manual editions.

Topic Nominations

To submit an idea for a future guideline, complete the topic nomination form linked below. Before you submit a topic, preview the list of questions on the form and gather the required information for your nomination. All topics are reviewed by the AAN Guidelines Subcommittee annually in January or February. To ask questions or for more information, reach out to guidelines@aan.com.

Submit a Guideline Topic

Permission for use

Requests for permission to reproduce AAN guidelines should be directed to the publisher.

For permission to reproduce AAN guideline derivative content (e.g., clinician tools and patient tools), email guidelines@aan.com.

Request An Affirmation of Value

The AAN acknowledges that many organizations and independent developers create high-quality guidelines and other evidence-based documents that may be of value to AAN members. We recognize these documents by granting the AAN's Affirmation of Value and listing affirmed documents on AAN.com. To submit a document for consideration, email your request to guidelines@aan.com. Before submitting a document for consideration, please read our full Policy on Affirmation of Value for External Publications.

Request a representative

The AAN often receives requests from external societies for neurological representation on panels for developing clinical practice guidelines, consensus guidelines, systematic reviews, and other similar publications. To submit a request for an Academy representative on your panel, please review our full Nomination of Representatives for External Societies Policy and email your request to guidelines@aan.com.

Guidelines FAQ

Q. What is the difference between a practice guideline and a quality measure?
A. Clinical practice guidelines are documents that include recommendations intended to optimize patient care that are based on an evidence-based systematic review. Quality measures are math equations to help understand how often health care services are consistent with current medical knowledge. Guideline recommendations form the denominator and numerator statements of quality measures.

Q. When do you update guidelines?
A. An update is considered when there is newly published evidence that significantly changes either the conclusions or the recommendations in a guideline. Guidelines and case definitions are assessed at least every three years to determine whether new literature has been published that would warrant an update. If the Guideline Subcommittee (GS) is aware of new evidence that may change conclusions or recommendations in the guideline prior to the next scheduled triennial review, the GS will review earlier.

Q. Do you collaborate with other guideline developers?
A. Medical associations and organizations regularly work together on medical practice guidelines when multiple groups or clinician specialties are involved with the treatment of a specific disease. There are two levels of collaboration:

Full collaboration: The development panel reflects equal representation from the collaborating societies. The societies involved sign a formal letter of agreement outlining terms of copyright ownership, simultaneous publication, division of costs before project initiation, and the method to be used.
Invited participation: AAN staff works with the societies to obtain a nominee. This individual serves as the official representative from the organization, providing updates to the organization’s board of directors. The organization has the opportunity to review and comment on the guideline during public comment periods and to endorse the guideline before publication.

Additionally, the AAN has several ways of endorsing or affirming the value of guidelines developed by other organizations. For more information, review the AAN endorsement policy.

Q. How do you choose what guidelines to develop?
A. Guideline projects are either updates to existing guidelines that have become out of date or are new projects. AAN members and others are welcome to submit topic nominations at any time. All topic nominations are reviewed by the GS. The GS reviews and votes on nominated topics annually using a ranking tool known as the Topic Nomination Priority Score (TNPS). The following criteria are taken into account:

Relevance to neurologists
Disease prevalence
Degree of practice variation or controversy
Project feasibility (amount of evidence, AAN and GS resources, whether collaboration with one or more external societies is required)
Impact on patient care and outcomes

Not all topics are accepted for development and the GS limits the number of topics awaiting development at any one time.

Q. What information/studies will be considered and included in the guidelines?
A. Authors review all available scientific studies on the chosen topic and select studies that 1) meet the inclusion criteria and 2) address the guideline's clinical questions. Inclusion criteria and questions are set before the literature search begins. Unpublished literature (also known as grey literature), such as supplements, book chapters, and studies that are unpublished or are not included in bibliographic retrieval systems, is also included to reduce publication bias.

Q. How is the level of evidence of each study determined?
A. For AAN guidelines, the risk of bias in studies is measured using a four-tiered classification scheme. In this scheme, studies rated Class I are judged to have a low risk of bias; Class II, a moderate risk of bias; Class III, a moderately high risk of bias; and Class IV, a very high risk of bias. The classification rating is also known as the level of evidence.

Q. What is GRADE?
A. GRADE stands for “Grading of Recommendations Assessment, Development and Evaluation.” GRADE is a transparent approach to grading the quality of evidence and strength of recommendations. The methodology is designed to help clinicians understand the strength of the science backing treatment recommendations, minimizing bias and aiding them in their interpretation.

Q. Who is on guideline development panels and how were they chosen?
A. Panels include members of the GS, an evidence-based medicine methodologist, neurologist subject matter experts, non-neurologists subject matter experts, representatives from physician and patient organizations, and patient representatives. The GS leadership reviews and approves all panel members. The lead author and over half of the members of the development panel cannot have conflicts of interest.

Steps of the AAN Evidence-based Guideline Development Process
1	Select topic	The Guidelines Subcommittee reviews topics submitted by committee members, AAN members, AAN sections, and others. Topics are prioritized by board-approved criteria (see FAQ)
2	Form development panel	Panel members include Subcommittee members, a methodology expert, neurologist subject matter experts, organization representatives, and patient representatives. All panel members must disclose all potential conflicts of interest. The AAN requires the lead author and over half of the panel members to have no conflicts of interest related to the guideline topic.
3	Develop clinical questions and protocol	Each clinical question must have the following four elements: Population, Intervention, Co-Intervention, and Outcome. Questions drive the research and are included in the guideline protocol. The questions should address an area of quality concern, controversy, confusion, or practice variation.
4	Post protocol for public comment	The protocol is a document that includes the clinical questions and the plan for the research strategy. The AAN posts the protocol on the AAN website for a 30-day public comment period to get feedback from members, organizations, and others affected by the disease to make sure the right questions are being asked.
5	Review and analyze evidence	A literature search is performed by a medical librarian, and then studies are reviewed by members of the development panel to determine if they meet inclusion criteria. Each study is reviewed by two independent reviewers. Developers then create an evidence table and populate with the essential characteristics of the included studies. Risk of bias is measured for each study using a four-tiered classification scheme. A modified version of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) process is used to determine whether the developer's confidence in the evidence is sufficient to support practice recommendations.
6	Synthesize evidence and develop conclusions	Data from the included studies is synthesized into conclusions. Conclusions are succinct statements that summarize the evidence in answer to a specific clinical question. Conclusions inform recommendations.
7	Develop recommendation statements	Actionable practice recommendations are based on evidence and also consider the following elements (see FAQ or Guideline Process Manual for full list): patient preferences, cost, and value of benefit relative to the risk.
8	Post draft guideline for public comment	The AAN posts the draft guideline on the AAN website for a 30-day public comment period to get feedback from members, organizations, and others affected by the disease, on the comprehensiveness and clarity of the document.
9	Journal peer-review	The Neurology^® journal solicits reviewers from its network to review and comment on the manuscript.
10	AAN approvals	After public comment, the draft guideline must receive approval from the AAN Guidelines Subcommittee, the AAN Quality Committee, and the AAN Institute Board of Directors before publishing
11	Develop derivative products	AAN guideline staff may develop tools for clinical and patient audiences, including the following: slide presentation, clinician summary, patient summary, guideline or case definition for clinicians, and algorithms.
12	*Publish in Neurology^®* and disseminate**	Guidelines are published in the AAN's journal, Neurology^®, and posted on the AAN website. AAN communications staff may launch a media publicity campaign which may include tactics such as social media posting and issuing a press release.
13	Review for currency	At least every three years, published guidelines are reviewed by the Guidelines Subcommittee for currency. Reviewed guidelines are reaffirmed as current, updated, or retired.