Abstract Details

Title Latent Cognitive Impairment: Association with Carotid Disease

Topic Aging and Dementia

Presentation(s) P04 - (-)

Poster/Presentation
Number 227

Objective

Background BACKGROUND: To study the prevalence of LCI among healthy elders and its associated factors.

Design/Methods DESIGN/METHODS: Among 636 subjects that have approached our "Brain Screen" program, we identified 78 community dwelling elderly persons (12.3%, 41 females) aged from 50 to 88 years (mean 65.4±8.3 years) without history of neurologic, psychiatric or systemic diseases and without any cognitive complaints, who scored 30 on the Minimental test exam (MMSE). All included individuals underwent Mindstreams - a computerized neuropsychological battery, as well as carotid Doppler ultrasound to measure intima media thickness (IMT).

Results RESULTS: 16 participants (20.5%), 10 males, had LCD defined as abnormal memory scores (range from 61.9 to 84.9, mean 76.9±7.5) on Mindstreams assessment vs. 102.2±8.4 in others, (p<0.001), defined as having LCI. The LCI group was older: 69.7±6.9 vs. 63.4±9.2 years (p=0.017) and less educated: 12.5±2.7 vs. 15.0±3.1 years (p=0.015). Other cognitive tests results were within the normal ranges; but still lower global cognitive scale 89.9±9.1 vs. 104.0±7.1 (p<0.001) and motor skills 89.9±13.4 vs. 100.3±10.7 (p=0.006). Carotid IMT was significantly thicker in the LCI group: 1.0±1.3 vs. 0.6±0.2 mm (p=0.023).

Conclusions CONCLUSIONS: As many as one fifth of community-dwelling elders who considered themselves to be completely healthy had LCI, probably associated with aging and incipient cerebro-vascular disease.

Authors/Disclosures
Yacov Balash, MD (Tel-Aviv Sourasky Medical Center) PRESENTER	No disclosure on file
Amos D. Korczyn, MD (Tel - Aviv University Medical School)	Dr. Korczyn has nothing to disclose.
	No disclosure on file
	No disclosure on file
Natan Bornstein, MD (Tel-Aviv Medical Center)	No disclosure on file
	No disclosure on file
	No disclosure on file