Abstract Details

Title Stroke Disparities Across Racial and other Minorities: Results from the “All of Us” Research Program

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) S30 - Cerebrovascular Disease and Interventional Neurology 3 (4:32 PM-4:40 PM)

Poster/Presentation
Number 004

Background “All of US” is a revolutionary research program that aims to collect and publicly share health data from one million Americans. One of its main goals is to accelerate research in minority populations traditionally underrepresented in biomedical research.

Objective We tested the hypothesis that cerebrovascular disease disproportionately affects minorities in the “All of Us” cohort.

Design/Methods We evaluated the first data release of “All of Us.” Inclusion criteria were age >18 years and consent to provide electronic health record (EHR) data and biological samples. Upon enrollment, participants completed several baseline surveys, including demographics and past medical history. We first conducted a cross-sectional analysis combining survey and EHR data to estimate the stroke prevalence upon enrollment. We subsequently used EHR data and time-to-event analysis via cox proportional hazards modeling to evaluate differences in stroke incidence. All analyses were performed in a secure informatic work space provided by the NIH.

Results The current “All of Us” cohort includes 224,143 participants, including 142,673 (64%) who answered the past medical history survey and provided EHR data. Minority groups included blacks (n=27,838), Hispanics (n=26,886), and persons who are older (n=14,445), disabled (n=14,321), uninsured (n=26,158), have low income (n=51,203) or belong to a sexual/gender minority (LGBTQIA+, n=17,646). There were 3,605 (2.5%) prevalent strokes. Stroke prevalence was significantly higher in several minority groups, including blacks and persons who are older, disabled and have low income (all p <0.05). In time-to-event analyses using data from 127,880 participants with available EHR data, there were 3,253 incident strokes (2.6%). Stroke incidence was significantly higher in blacks and Hispanics (p<0.001).

Conclusions Among Americans enrolled in “All of Us,” several minority groups have a disproportionately higher burden of stroke. The All of Us program provides a powerful tool to accelerate research focused on minorities and close the gap in knowledge that leads to significant health disparities.

Authors/Disclosures
Julian Acosta, MD (Yale) PRESENTER	Dr. Acosta has nothing to disclose.
Audrey Leasure	Ms. Leasure has nothing to disclose.
	No disclosure on file
Natalia Szejko, MD, PhD (University of Calgary)	Dr. Szejko has nothing to disclose.
Victor M. Torres-Lopez, MA (Yale University)	Mr. Torres-Lopez has nothing to disclose.
Kevin N. Sheth, MD, FAAN (Yale UniversityDivision of Neuro and Critical Care)	Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ceribell. Dr. Sheth has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Zoll. Dr. Sheth has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NControl. Dr. Sheth has received stock or an ownership interest from Astrocyte. Dr. Sheth has received stock or an ownership interest from Alva. The institution of Dr. Sheth has received research support from Biogen. The institution of Dr. Sheth has received research support from Novartis. The institution of Dr. Sheth has received research support from Bard. The institution of Dr. Sheth has received research support from Hyperfine. Dr. Sheth has received intellectual property interests from a discovery or technology relating to health care.
Guido J. Falcone, MD (Yale School of Medicine)	The institution of Dr. Falcone has received research support from NIH. The institution of Dr. Falcone has received research support from AHA.