Abstract Details

Title Modulation of Resting State Networks by Antiseizure Medications in Patients With Idiopathic Generalized Epilepsy

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) S10 - Epilepsy and Clinical Neurophysiology (EEG) 2 (4:00 PM-4:08 PM)

Poster/Presentation
Number 001

Background In IGE seizure control is usually achieved with ASMs. Effects of medications in the brain connectivity of patients with IGE is still under investigation. We hypothesized that ASMs concentration may directly influence RSNs.

Objective Investigate the effects of antiseizure medications (ASMs) in the resting state networks (RSNs) in patients with idiopathic generalized epilepsies (IGE).

Design/Methods 25 patients with IGE and 25 controls were enrolled. All subjects underwent 3T MRI. T1 sequences were used for anatomical analysis. BOLD fMRI time-series during rest were acquired for functional connectivity. ASMs ratios were calculated based on the number of medications and the blood levels. Image processing was conducted using Conn toolbox. Functional time-series were realigned, co-registered with the anatomical images, smoothed and submitted to denoising. Statistical analysis of regions of interest (ROI) to ROI connectivity including default mode (DMN) and salience networks (SN) was performed using general linear model (GLM) with false discovery rate correction. Analysis was conducted exploring the correlations between functional maps and ASMs ratio.

Results 55 connections among 11 ROIs were investigated. Correlation analysis showed 2 mains clusters of positive correlations between functional connectivity and ASMs. The first cluster involved connections among DMN nodes (medial prefrontal, posterior cingulate and lateral parietal cortex; F=66.4, p<0.001) and the second SN nodes (anterior insula, anterior cingulate, rostral prefrontal and supramarginal gyrus cortex; F=88.9, p<0.001). A cluster of anticorrelation between ASMs and RSNs was disclosed connecting DMN and SN (F=18.6, p<0.001).

Conclusions ASMs levels were mainly positively correlated with RSNs. The connections between DMN and SN were positively influenced by ASMs. In the normal brain during the rest-state DMN is activated and SN deactivated keeping an antagonistic interaction. Our findings indicate that ASMs increased intranetwork connectivity of RSNs and also reduced their interaction. Therefore, ASMs may modulate the brain networks of patients with IGE by normalizing their functionality.

Authors/Disclosures
Júlia Espinosa (UNESP - Botucatu) PRESENTER	Júlia Espinosa has nothing to disclose.
	No disclosure on file
Luiz E. Betting	Dr. Betting has nothing to disclose.