Abstract Details

Title The role of marriage and sleep efficiency in cognitive decline: Results from Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Topic Sleep

Presentation(s) Sleep Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 018

Background Compared to single individuals, married people have better NC and sleep health, but these relationships are largely unknown for Hispanics/Latinos. As Hispanics/Latinos carry larger burden of NC decline and sleep disturbances than non-Hispanic whites, it is a substantial public health concern.

Objective To determine if sleep modifies the associations of marital-status with neurocognitive function (NC) and NC change in 7 years among Hispanics/Latinos.

Design/Methods We examined the SOL-INCA sample (45-74 years old (n=5,872, mean age=56.4±8.1, 55% female), an ancillary study to HCHS/SOL, a longitudinal, multicenter, community-based cohort of diverse US Hispanic/Latinos. Baseline data included demographics including marital status (married, separated/divorced/widowed, cohabiting, and single), sleep questionnaires and measures of NC (performance at baseline, 7-years later, on average, and 7-year change). NC was assessed using learning and memory (B-SEVLT-sum and -recall), language (word-fluency), processing speed (Digit-Symbol-Substitution) and mental status (SIS). We used complex survey linear regression to evaluate associations between marital-status with neurocognitive function and change, and test whether sleep risks modify these associations. Models were incrementally adjusted for demographic, socioeconomic and cultural factors.

Results Half (50.3%) of the individuals were married, 27.6% separated/divorced/widowed, 16.8% single, and 5.3% cohabited. In age, sex, and education-adjusted models, being married was associated with better global and domain specific cognitive performance at baseline (B_Global=0.153, SE=0.030) but not at 7-year follow-up. These associations were attenuated through adjustment for socioeconomic and cultural factors. Cohabiters had more NC deficits and declines compared with other marital groups in the context of longer sleep duration and insomnia.

Conclusions

Marriage was associated with higher initial NC function. Individuals who cohabitate may be more susceptible to sleep-related cognitive deficits/declines and may benefit most from sleep interventions.

Authors/Disclosures
Natalia Rincon, MD (Columbia University) PRESENTER	Dr. Rincon has nothing to disclose.
	No disclosure on file
Wassim Tarraf	No disclosure on file
	No disclosure on file
Jianwen Cai (University of North Carolina at Chapel Hill)	No disclosure on file
Martha Daviglus	No disclosure on file
Linda Gallo	Linda Gallo has nothing to disclose.
	No disclosure on file
Ariana Stickel	No disclosure on file
Phyllis C. Zee, MD, PhD (Northwestern Univ Medical School)	Dr. Zee has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sanofi-Aventis. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Harmony Biosciences. Dr. Zee has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz Pharmaceuticals Inc.. Dr. Zee has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. The institution of Dr. Zee has received research support from National Institutes of Health. The institution of Dr. Zee has received research support from Vanda. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received intellectual property interests from a discovery or technology relating to health care. Dr. Zee has received publishing royalties from a publication relating to health care.
Hector Gonzalez	Hector Gonzalez has nothing to disclose.
Alberto Ramos, MD, FAAN (Miller School of Medicine, University of Miami)	Dr. Ramos has received personal compensation in the range of $500-$4,999 for serving as a Consultant for One Care Media, LLC. Dr. Ramos has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for National Heart, Lung and Blood Institute . The institution of Dr. Ramos has received research support from Axsome pharmaceutical. The institution of Dr. Ramos has received research support from NIH. The institution of Dr. Ramos has received research support from National Institutes of Aging/NIH. Dr. Ramos has received personal compensation in the range of $500-$4,999 for serving as a Clinical Advisor with Neurogeneces, Inc. Dr. Ramos has a non-compensated relationship as a Editorial Board with Chest Scientific Journal that is relevant to AAN interests or activities.