Abstract Details

Title Association of the Mediterranean Diet and Cognition Function among Hispanics/Latinos

Topic Aging and Dementia

Presentation(s) S15 - Aging and Dementia 1 (4:30 PM-4:42 PM)

Poster/Presentation
Number 006

Background

High adherence to the MeDi has been associated with lower cognitive impairment. However, Hispanics/Latinos have rarely been studied.

Objective Investigate the associations between adherence to the Mediterranean Diet (MeDi) with cognitive performance among Hispanics/Latinos.

Design/Methods We included 6,321 participants aged 45-74 at baseline from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) ancillary study, the SOL-Investigation of Neurocognitive Aging (SOL-INCA). Participants completed 24-hour dietary recalls at baseline (2008-2011). Food and nutritional components were used to calculate a MeDi score (MeDiS). MeDi adherence was categorized as low (MeDiS=0-4), moderate (MeDiS=5-6) or high (MeDiS=7-9). Neurocognitive tests (Brief-Spanish English Verbal Learning Test Sum [B-SEVLT-Sum], B-SEVLT-Recall, Word Fluency [WF], and Digital Symbol Substitution [DSS]) were administered at baseline and follow-up (2015-2018). Cognitive change was calculated using (cognitive score at follow-up minus predicted cognitive score at follow-up)/root mean square error. Complex survey linear regression analyses were used to determine the association between MeDi adherence groups and z score-transformed cognitive outcomes as well as cognitive change after adjusting by age, sex, education and baseline sociodemographic and clinical characteristics.

Results

Mean baseline age±SE was 56.1±0.2 years and 42% were males. Mean MeDiS±SE was 5.05±0.04. MeDi adherence frequencies were 32%, 45%, and 25% for low, moderate and high, respectively. The average elapsed time between visits was 6 years. Compared to the low adherence group, adults with high adherence had higher B-SEVLT-Sum (β=0.16; p<0.001) and B-SEVLT-Recall (β=0.20; p<0.001) scores at baseline, and higher B-SEVLT-Sum (β=0.21; p<0.001) and B-SEVLT-Recall (β=0.23; p<0.001) scores at follow-up. No significant differences were observed for WF and DSS (p>0.05). Cognitive change in the low vs. high MeDi adherence groups was significant for B-SEVLT-Sum (β=0.13; p<0.01) and B-SEVLT-Recall (β=0.15; p<0.01), but not for WF and DSS (p<0.05).

Conclusions Among diverse middle-age and older Hispanics/Latinos, high MeDi adherence was associated with higher episodic learning and memory and decreased 6-year memory decline.

Authors/Disclosures
Gabriela Trifan, MD (UIC, Department of Neurology) PRESENTER	Dr. Trifan has nothing to disclose.
Bayan Moustafa, DO	Dr. Moustafa has nothing to disclose.
Carmen Isasi	No disclosure on file
Richard B. Lipton, MD, FAAN (Albert Einstein College of Medicine)	Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Allergan/Abbvie. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Amgen. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biohaven. Dr. Lipton has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Eli Lilly. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for GlaxoSmithKline. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Teva. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Vedanta. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Grifols. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Pfizer. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Axon. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Satsuma. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cool Tech. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BDSI. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Linpharma. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Allergan/Abbvie. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biohaven. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. Dr. Lipton has stock in Biohaven. Dr. Lipton has stock in Manistee. Dr. Lipton has stock in Axon. Dr. Lipton has stock in CoolTech. The institution of Dr. Lipton has received research support from Teva. The institution of Dr. Lipton has received research support from Amgen. The institution of Dr. Lipton has received research support from Allergan/Abbvie. The institution of Dr. Lipton has received research support from Gammacore. The institution of Dr. Lipton has received research support from Axsome. The institution of Dr. Lipton has received research support from Charleston Labs. The institution of Dr. Lipton has received research support from Eli Lilly. The institution of Dr. Lipton has received research support from Satsuma. The institution of Dr. Lipton has received research support from NIH . The institution of Dr. Lipton has received research support from Veterans Administration. Dr. Lipton has received publishing royalties from a publication relating to health care.
	No disclosure on file
Jianwen Cai (University of North Carolina at Chapel Hill)	No disclosure on file
Wassim Tarraf	No disclosure on file
Hector Gonzalez	Hector Gonzalez has nothing to disclose.
Ariana Stickel	No disclosure on file
	No disclosure on file
Gregory Talavera (San Diego State University)	No disclosure on file
Martha Daviglus	No disclosure on file
Fernando D. Testai, MD, PhD, FAAN (University of Illinois at Chicago)	Dr. Testai has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Testai has received publishing royalties from a publication relating to health care.