Abstract Details

Title Ultra High-field MRI Versus 1.5/3 T MRI in the Detection of Cerebrovascular Disease

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P15 - Poster Session 15 (5:30 PM-6:30 PM)

Poster/Presentation
Number 13-005

Background

Given the 2017 FDA approval of 7T MRI for clinical use, it is urgently necessary to establish the cerebrovascular conditions and diagnostic questions best addressed by MRI instruments that utilize 7T compared to lower field systems at 1.5T and 3T.

Objective

To compare the efficacy of 7-Tesla (7T) versus 1.5T and 3T in the diagnosis and management of cerebrovascular disease.

Design/Methods

A systematic search following PRISMA (Preferred Reporting for Systematic Reviews and Meta-Analysis) guidelines was performed on PubMed and Web of Science with a pre-planned search strategy, which yielded 368 reports after removing duplicates. When imposing a selection criteria that included direct comparison of 1.5/3T versus 7T for cerebrovascular disease, 20 studies remained. For meta-analysis, we utilized the metafor package on R.

Results

In 20 studies, there are 387 total patients where atherosclerosis, arteriovenous malformation, and aneurysm are the most examined pathologies. Three studies reported the mean number and variance of lesions per patient comparing low-field and 7T imaging. 7T MRI showed a pooled effect of 2.49 more lesions (SMD, 95% CI: 0.38-4.61, p <0.05) using a random-effects model. From seven studies that reported the aggregated number of lesions instead of lesions per patient, 7T identified 0.8 more lesions (95% CI: 0.12-1.48, p <0.05), demonstrating the superiority of 7T imaging in detecting lesions when compared to 1.5T/3T imaging. Seven of the studies utilized the same MRI sequences in the low-field and high-field scans, and 13 studies ran at least one distinct experiment at one of the field strengths.

Conclusions

MRI can detect more cerebrovascular lesions at 7T compared to at lower-field. More studies are needed to establish 7T systems as the preferred approach to show the extent and location of cerebrovascular disease. Future studies may also demonstrate superior 7T characterization of inflammation as a key role in determining risk of cerebral ischemia or hemorrhage.

Authors/Disclosures
David T. Krist PRESENTER	Mr. Krist has nothing to disclose.
Rachael Tessem	Ms. Tessem has nothing to disclose.
	No disclosure on file
Tracy Kao	Miss Kao has nothing to disclose.
	No disclosure on file
Wael Ali Mostafa	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file