Abstract Details

Title Association Between Mean Platelet Volume And Severity Of Acute Ischaemic Stroke Assessed By Modified Rankin Scale

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P18 - Poster Session 18 (5:30 PM-6:30 PM)

Poster/Presentation
Number 13-002

Background

There is evidence that platelet function is accentuated in acute ischaemic stroke. MPV measured at this stage may well reflect (at least in part) the potential reactivity of platelets prior to the stroke. The mean platelet volume (MPV) is one of the most commonly used laboratory markers related platelet functions.

Objective

1. To determine the mean platelet volume in patients of acute ischaemic stroke. 2. To compare the mean platelet volume between cases and controls. 3. To study the association between Mean Platelet Volume (MPV) and the severity of acute ischaemic stroke assessed by Modified Rankin Scale.

Design/Methods The study was carried in 100 patients diagnosed with an acute ischaemic stroke within 48 hours of onset of symptoms. Mean platelet volume of all such patients and controls were measured and it was correlated with severity of ischemic stroke. The Statistical software namely SPSS 25.0 was used for analysis of data. Microsoft excel was used for preparation of master chart and Microsoft Word was be used for creating tables, graphs and charts.

Results MPV was found to be higher in patients of acute ischaemic stroke as compared to controls. The median (IQR) of MPV (fl) in the Group: Case group was 10 (1.75). The median (IQR) of MPV(fl) in the Group: Control group was 7.7 (1.3). There was a significant difference between the 2 groups in terms of MPV (fl) (W = 9188.000, p = <0.001), with the median MPV (fl) being highest in the Group: Case group.

Conclusions

Our study showed that Mean Platelet volume is higher in patients of acute ischaemic stroke as compared to controls. 2. Hence, Mean Platelet Volume can be regarded as an independent risk factor for ischaemic stroke. 3. Elevated Mean Platelet Volume is associated with more severe morbidity ie. Higher Modified Rankin score.

Authors/Disclosures
Dinesh M. Chaudhari, DNB (Indraprastha Apollo Hospital, New Delhi) PRESENTER	Dr. Chaudhari has nothing to disclose.
Charchit Gupta, DNB (Indraprastha Apollo Hospital)	No disclosure on file
Pushpendra N. Renjen, MD (Indraprastha Apollo Hospitals New Delhi)	Dr. Renjen has nothing to disclose.
Anjali Mishra	No disclosure on file