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Abstract Details

Petechiae: An Atypical Initial Presentation of Seizure
Epilepsy/Clinical Neurophysiology (EEG)
P18 - Poster Session 18 (5:30 PM-6:30 PM)
10-006
There have been cases reporting association of petechiae with seizures, however, it is rare that a patient presents with only petechiae or skin manifestations as an initial presentation of a seizure.  Here, we present a case of a 25-year-old man who would develop unexplained intermittent petechiae which were ultimately linked with seizures and a new diagnosis of epilepsy.
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A 25-year-old man with no known past medical history presented with a 3-year history of intermittent petechiae.

He initially noticed petechiae upon awakening more prominent over periorbital region occurring upto once a month with gradual progression to the face, torso, and shoulders during these episodes. He subsequently began experiencing intermittent paresthesias of the right upper extremity followed by headache. The initial workup including hematological, immunological, and rheumatological workup was negative.  CT head did not show any acute pathology.

He was then noted to have a seizure - ictal cry with right-sided head version and eye deviation followed by a generalized tonic-clonic activity lasting for a minute. On presentation to hospital, he was noted to have petechiae in the same distribution mentioned above. The petechiae resolved on the same day. Over the next few days, he had two more seizures with similar transient petechiae. He was then diagnosed with recurrent seizures as cause of transient petechiae.

He underwent MRI brain revealing focal cortical dysplasia in the left peri-rolandic region in postcentral gyrus and electroencephalogram which was unremarkable. He was started on levetiracetam and he remains seizure-free and petechiae-free since then.

Petechiae associated with seizures has been referenced in literature. Mechanism of petechiae is likely associated with extravasation of RBCs due to increased intrathoracic pressure causing ruptured capillaries. In our patient petechiae did not return after initiation of levetiracetam. Petechiae are a rare but important clinical sign that could be associated with seizures.
Authors/Disclosures
Shivanee Sodani, MBBS
PRESENTER
Dr. Sodani has nothing to disclose.
Musab Zorlu, MD Dr. Zorlu has nothing to disclose.
Hasmik Amirjanyan, MD Dr. Amirjanyan has nothing to disclose.
Swetha Ade, MD (Hartford Hospital) Dr. Ade has nothing to disclose.
Ajay M. Tunguturi, MD (Hartford HealthCare) Dr. Tunguturi has nothing to disclose.