Abstract Details

Title Prospective, Multicenter, International Registry of Deep Brain Stimulation for Essential Tremor

Topic Movement Disorders

Presentation(s) P15 - Poster Session 15 (5:30 PM-6:30 PM)

Poster/Presentation
Number 5-005

Background

Essential Tremor (ET) is one of the most common neurological diseases affecting about 0.9% of the world population (Louis ED., et al. Mov Disord 2010 Apr 15;25(5):534-41). ET treatment is focused on medical management of motor symptoms and includes pharmacotherapy and ventral intermediate nucleus (VIM) thalamotomy, which is being largely replaced by thalamic Deep Brain Stimulation (DBS) as the surgical treatment of choice. DBS of the VIM thalamus is recommended as a therapeutic option for appropriate subjects with ET (Elble RJ., et al. Expert Rev Neurother. 2018 Apr; 18(4):303-321). New insights regarding the real-world, clinical use of VIM DBS may be acquired through the implementation of large, multi-center patient registries.

Objective

Here, we describe the initiation of a new ET patient registry for patients implanted with a multiple-source, constant- current DBS system capable of providing directionality for use in the management of Essential Tremor motor symptoms.

Design/Methods

This is a prospective, on-label, multi-center, international DBS registry conducted at up to 50 implanting centers. All participating subjects will be implanted with a multiple-source, constant-current DBS system (Vercise, Boston Scientific). Subjects are followed for up to 3-years post implantation where their overall improvement in quality of life and ET symptoms are evaluated. Clinical endpoints evaluated at baseline and during study follow-up timepoints include: Quality of Life in Essential Tremor Questionnaire (QUEST), Fahn-Tolosa- Marin Rating Scale (FTMTRS), and Global Impression of Change. Occurrence of adverse events will be documented.

Results

Collection of data and results from this on-going registry for Essential Tremor is currently on-going and will be presented.

Conclusions

This on-going registry represents the first comprehensive, large scale collection of real-world outcomes and evaluation of safety and effectiveness of a multiple-source, constant-current DBS system capable of providing directionality for use in the treatment of Essential Tremor.

Authors/Disclosures
Guenther Deuschl, MD, FAAN (Dept. of Neurology, Christain-Albrechts Univ) PRESENTER	Dr. Deuschl has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Boston Scientific. Dr. Deuschl has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boston Scientific Cavion Functional Neuromodulation. The institution of Dr. Deuschl has received research support from Medtronic. Dr. Deuschl has received publishing royalties from a publication relating to health care.
P.R. Schuurman	No disclosure on file
Lilly Chen (Boston Scientific)	Lilly Chen has received personal compensation for serving as an employee of Boston Scientific .
Roshini Jain	Roshini Jain has received personal compensation for serving as an employee of Boston Scientific. Roshini Jain has received stock or an ownership interest from Boston Scientific.