Abstract Details

Title The Association Between Lifestyle Factors and Huntington´s Disease Mortality

Topic Movement Disorders

Presentation(s) P3 - Poster Session 3 (5:30 PM-6:30 PM)

Poster/Presentation
Number 5-004

Background Lifestyle factors may contribute to the progression of HD but little is known about factors that influence mortality

Objective

To examine whether caffeine or alcohol consumption, smoking, physical activity, and Mediterranean diet (MeDi) adherence is associated with survival among a Spanish cohort of patients with Huntington´s disease (HD) with an .8-year surveillance period.

Design/Methods

Observational, longitudinal, national study. Eighty-nine subjects were selected from a Spanish cohort of patients participating in the European Huntington Disease Network (EHDN). Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence), coffee/tea, alcohol (< 30 gr/day) consumption, physical activity, and current tobacco use were assessed at baseline. Sociodemographics, comorbidity, body mass index (BMI), caloric intake and macro/micronutrients information, HD severity course using the Unified HD Rating Scale (UHDRS), Psychiatric Behavioral Assessment (PBA), pharmacological and non-pharmacological treatment, and Total functional capacity (TFC) scores were collected. Cox proportional hazards models were conducted to determine the association of lifestyle factors with mortality.

Results Sixteen deaths were recorded. In univariate Cox regression analysis, lower risk for mortality was associated with higher BMI (HR=0.86, 95% CI 0.74, 0.99), moderate alcohol consumption (HR 0.12, 95% CI 0.002, 0.53), coffee/tea consumption (HR 0.14, 95% CI 0.05, 0.41), lower disease severity (TFC) (HR=0.76 95% CI 0.66, 0.88), with a trend for higher MeDi adherence (HR=0.77, 95% CI 0.54, 1.09). Instead, higher risk for mortality was associated with higher CAG repeats (HR 1.09, 95% CI 1.002, 1.09). In multivariate Cox regression models adjusted for age, CAG repeats, physical activity, tobacco use, alcohol and coffee/tea consumption and MeDi adherence, lower risk for mortality was only associated with coffee/tea consumption (HR 0.10 95% CI 0.03, 0.31, p<0.0001).

Conclusions This national-based study suggests that coffee/tea consumption significantly influences HD mortality. Lifestyle practices present modifiable factors that can improve mortality in genetic diseases such as HD.

Authors/Disclosures
Esther Cubo Delgado, MD, FAAN (Fundacion Burgos Investigacion Salud CIF G09254616) PRESENTER	Dr. Cubo Delgado has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie. Dr. Cubo Delgado has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Zambon. Dr. Cubo Delgado has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Abbvie. The institution of Dr. Cubo Delgado has received research support from Spanish health ministry. The institution of Dr. Cubo Delgado has received research support from European union grant.
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Alvaro Garcia Bustillo	No disclosure on file
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