Abstract Details

Title Is Rhabdomyolysis after SARS-CoV-2 infection a Factor of Poor Prognosis?

Topic Neuromuscular and Clinical Neurophysiology (EMG)

Presentation(s) P11 - Poster Session 11 (11:45 AM-12:45 PM)

Poster/Presentation
Number 11-006

Background Acute skeletal muscle injury including rhabdomyolysis was reported in COVID-19 patients.

Objective Investigate whether rhabdomyolysis is a factor of a poor prognosis in COVID-19 patients.

Design/Methods Using medical records of patients admitted between March 2020 and March 2021 at University Hospital, Newark NJ, we identified patients with COVID-19 infection and rhabdomyolysis (COVID-19A). We compared outcomes of COVID-19A to: COVID-19 patients without rhabdomyolysis (COVID-19NA), non-COVID-19 patients with rhabdomyolysis (non-COVID-19A) and non-COVID-19 patients without rhabdomyolysis (non-COVID-19NA). ICD10 codes were used to identify rhabdomyolysis and COVID-19 patients.

Results Among a total of 38,467 patients, 1,356 were diagnosed with COVID-19. The incidence of rhabdomyolysis was significantly higher in COVID-19 patients compared to non-COVID-19. (5.6% vs 1.7% p<0.001). The average length of hospitalization in days (LoS) and mortality rate were significantly higher in COVID-19A compared to COVID-19NA and non-COVID-19A as well as non-COVID-19NA, respectively 13, 61.8% vs. 8, 18.9% vs. 10, 11% vs. 6, 2.8% (p<0.01). Discharge rate to skilled nursing facilities (SNF) and to hospices were significantly higher in COVID-19A compared to COVID-19NA as well as non-COVID-19N, respectively 18.4% vs. 11.8% vs. 22.1% (p<0.01). However, discharge to these facilities was highest among non-COVID-19A (22.2%). ICU admission rates were significantly higher in COVID-19A compared to COVID-19NA and non-COVID-19A as well as non-COVID-19N, respectively 39.5% vs. 14% vs. 34.3 vs. 20.2% (p<0.01).

Conclusions Our study demonstrated a significant increased incidence of rhabdomyolysis in COVID-19 patients which is associated with increased mortality rate, LoS, and a higher rate of discharge to SNF and to hospice. Work is in progress to investigate whether rhabdomyolysis is an independent risk factor of poor prognosis of COVID-19 patients.

Authors/Disclosures
PRESENTER	No disclosure on file
Mohsen Ahmed (New Jersey Medical school)	Mr. Ahmed has nothing to disclose.
Mustafa Jaffry	Mr. Jaffry has nothing to disclose.
Kranthi K. Mandava	Mr. Mandava has nothing to disclose.
Kazim Jaffry	Mr. Jaffry has nothing to disclose.
Nizar Souayah, MD, FAAN (NJMS)	Dr. Souayah has received publishing royalties from a publication relating to health care.