Abstract Details Title Regaining control of movement following a spinal cord injury using Epidural Electrical Stimulation coupled with Task Specific Training Topic Neuro-rehabilitation Presentation(s) P18 - Poster Session 18 (5:30 PM-6:30 PM) Poster/Presentation Number 7-005 Background Spinal cord injury (SCI) is a devastating illness resulting in paralysis Regaining voluntary control of movement requires reorganization of the residual descending sensory-motor pathway. Epidural electrical stimulation (EES) combined with task-specific training enhances the functional reorganization of spinal pathways and improve motor recovery. Objective Utilizing Epidural electrical stimulation (EES) combined with task-specific training to enable motor function in individuals with chronic paralysis due to spinal cord injury (SCI). Design/Methods Three participants with mid thoracic complete SCI ( ASIA GRADE A) with mean duration of 3 years undergone 12 months (960 sessions) of rehabilitation with EES after implantation of a 16-electrode array on the surface of the lumbosacral spinal cord. Stimulus evoked compound action potential were analysed with reference to latency , amplitude. Using Mapping technique voluntary movement across each joints were analysed in supine, sitting and standing with partial body weight suspended gait trainer (BWST). Lower extremity motor output obtained during clinician-assisted ES-enabled treadmill stepping with BWST. Results In all three participants, 2 Hz stimulation with 2 volts elicited stimulus coupled CMAP characteristic for posterior root stimulation. stepping like movements were obtained with Stimulation frequencies between 15 to 25 Hz, and amplitude between 5 to 8 volts elicited sustained tonic and rhythmic activity. The hip and knee extensors showed good extension with lower frequencies (15 to 25 Hz). Sustained stimulation to the lumbar cord through posterior root effectively recruited sustained extension and rhythmic flexion/ extension movement. Also, there was 70 % reduction in body weight support was achieved with epidural stimulation (ES) enabled stepping movement when compared with 20 % BWS without epidural stimulation. Conclusions Epidural stimulated- enabled BWST resulted in timely and purposeful activation of the lower extremities muscles, improved independence and decreased clinician assistance. It improved ability to walk voluntarily using body weight suspended support trainer and a wheeled walker. Authors/Disclosures PRESENTER No disclosure on file No disclosure on file