Abstract Details

Title Disability in Migraine: Multicountry Results From the CaMEO-International Study

Topic Headache

Presentation(s) S41 - Emergent Sciences and Top Headache Research (3:42 PM-3:54 PM)

Poster/Presentation
Number 002

Background Although individual studies evaluating headache burden are available from many countries, few studies have been conducted across multiple countries using the same methodology.

Objective To describe disability among individuals with migraine.

Design/Methods Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) was a cross-sectional, web-based survey conducted in 2021-2022 in Canada, France, Germany, Japan, the United Kingdom, and the United States. The American Migraine Study/American Migraine Prevalence and Prevention Study diagnostic questionnaire identified respondents with migraine based on modified International Classification of Headache Disorders, 3rd edition, criteria. This analysis evaluated migraine burden using the Migraine-Specific Quality of Life Questionnaire (MSQ) and the Work Productivity and Activity Impairment Questionnaire (WPAI). The MSQ is a 14-item questionnaire that measures the effect of migraine on daily functioning across 3 domains, with higher scores corresponding to better quality of life. The WPAI evaluates the impact of migraine on work productivity and regular activities.

Results This analysis included 14,492 respondents with migraine (~2400 from each country). Mean (SD) MSQ scores ranged from 57.7 (23.4) in Canada to 63.3 (21.1) in France for the role function restrictive domain, 67.6 (22.9) in Germany to 77.3 (22.7) in Japan for the role function preventive domain, and 63.9 (29.1) in the US to 69.2 (24.8) in France for the emotional function domain. Based on the WPAI, the mean (SD) percentage of work missed (absenteeism) ranged from 4.3% (16.2) in France to 9.0% (21.7) in Germany, percentage of work impaired (presenteeism) ranged from 31.2% (28.0) in France to 47.8% (28.6) in Japan, percentage of overall work impaired ranged from 33.5% (30.3) in France to 49.4% (29.4) in Japan, and percentage of activity impaired ranged from 39.3% (30.2) in France to 50.7% (28.4) in Japan.

Conclusions For every country surveyed, migraine is associated with substantial burden, including poor quality of life and work/activity impairment.

Authors/Disclosures
Richard B. Lipton, MD, FAAN (Albert Einstein College of Medicine) PRESENTER	Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Allergan/Abbvie. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Amgen. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biohaven. Dr. Lipton has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Eli Lilly. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for GlaxoSmithKline. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Teva. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Vedanta. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Grifols. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Pfizer. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Axon. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Satsuma. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cool Tech. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BDSI. Dr. Lipton has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Linpharma. Dr. Lipton has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Allergan/Abbvie. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biohaven. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Dr. Lipton has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. Dr. Lipton has stock in Biohaven. Dr. Lipton has stock in Manistee. Dr. Lipton has stock in Axon. Dr. Lipton has stock in CoolTech. The institution of Dr. Lipton has received research support from Teva. The institution of Dr. Lipton has received research support from Amgen. The institution of Dr. Lipton has received research support from Allergan/Abbvie. The institution of Dr. Lipton has received research support from Gammacore. The institution of Dr. Lipton has received research support from Axsome. The institution of Dr. Lipton has received research support from Charleston Labs. The institution of Dr. Lipton has received research support from Eli Lilly. The institution of Dr. Lipton has received research support from Satsuma. The institution of Dr. Lipton has received research support from NIH . The institution of Dr. Lipton has received research support from Veterans Administration. Dr. Lipton has received publishing royalties from a publication relating to health care.
Zaza Katsarava, MD	Zaza Katsarava, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Allergan. Zaza Katsarava, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lilly. Zaza Katsarava, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Zaza Katsarava, MD has received personal compensation in the range of $500-$4,999 for serving as a Consultant for TEVA. Zaza Katsarava, MD has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Lilly. Zaza Katsarava, MD has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva. Zaza Katsarava, MD has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis.
Dawn C. Buse, PhD (Dawn C. Buse, PhD)	Dr. Buse has received personal compensation for serving as an employee of Vector Psychometric Group. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie-Allergan. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amgen. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lilly. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lundbeck. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Collegium. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Teva. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lilly. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Abbvie-Allergan. Dr. Buse has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lundbeck. Dr. Buse has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Pain and Headache Reports. The institution of Dr. Buse has received research support from Amgen. The institution of Dr. Buse has received research support from FDA. The institution of Dr. Buse has received research support from National Headache Foundation.
Elizabeth Leroux, MD (Centre Medical Brunswick)	Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Teva Innovation Canada. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Lundbeck. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis. Dr. Leroux has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbvie /Allergan. Dr. Leroux has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Lin Pharmaceutical. Dr. Leroux has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Paladin. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Teva. Dr. Leroux has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Allergan. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Allergan/Abbvie. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Eli Lilly. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Teva. Dr. Leroux has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Novartis. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Lundbeck. Dr. Leroux has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Pfizer.
Michel Lanteri-Minet, MD (CHU De Nice)	Dr. Lanteri-Minet has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Abbvie. Dr. Lanteri-Minet has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eli Lilly. The institution of Dr. Lanteri-Minet has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eli Lilly. Dr. Lanteri-Minet has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Lundbeck. Dr. Lanteri-Minet has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medtronic. The institution of Dr. Lanteri-Minet has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Medtronic. Dr. Lanteri-Minet has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for TEVA. Dr. Lanteri-Minet has received personal compensation in the range of $500-$4,999 for serving as a Consultant for UPSA. Dr. Lanteri-Minet has received personal compensation in the range of $500-$4,999 for serving as a Consultant for IPSEN. Dr. Lanteri-Minet has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Pfizer. The institution of Dr. Lanteri-Minet has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Pfizer. Dr. Lanteri-Minet has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Savia BioElectronics. Dr. Lanteri-Minet has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ReckittBenckiser. The institution of Dr. Lanteri-Minet has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Zambon. Dr. Lanteri-Minet has received publishing royalties from a publication relating to health care.
	No disclosure on file
Manjit S. Matharu, MD	No disclosure on file
Katherine Sommer	Katherine Sommer has received personal compensation for serving as an employee of AbbVie. Katherine Sommer has stock in AbbVie.
Michael Seminerio	Michael Seminerio has received personal compensation for serving as an employee of AbbVie.
Kristina M. Fanning, PhD (MIST Reserach)	The institution of Kristina Fanning has received research support from Abbvie. The institution of Kristina Fanning has received research support from NYC Langone Health . The institution of Kristina Fanning has received research support from Allay Lamp. The institution of Kristina Fanning has received research support from Juva Health.