2021 Annual Meeting | N4 - Neuroscience in the Clinic: CAR-T Cell Therapy: Neurologic Applications and Neurotoxicity

Date Tuesday 04/20/21

Time 05:00 PM - 07:00 PM EDT Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Neuroscience in the Clinic Session

Director(s) H. E. Hinson, MD, MCR, FAAN, Antonio M. Omuro, MD, FAAN

Topic(s) General Neurology

Learning Objectives At the conclusion of the program, attendees will recognize neurologic toxicities associated with immunotherapy and get an update on best practises for treatment of these toxicities, as well as to have a better understanding of the underlyingbiology to the extent it is understood.

CME Available 2.00 CME credits

Core Competencies Patient Care & Procedural Skills, Medical Knowledge

Program Level Intermediate

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Neurohospitalist

Teaching Styles Case-based, Didactic

Program Materials Program Evaluations

Event Timeline
05:00 PM - 05:05 PM EDT	Introduction	Introduction Antonio M. Omuro, MD, FAAN
05:05 PM - 05:25 PM EDT	Speaker	Case Presentation H. E. Hinson, MD, MCR, FAAN
05:25 PM - 05:55 PM EDT	Speaker	Basic Science Behind Cancer Immunotherapy and Clinical Implications Bianca Santomasso, MD
05:55 PM - 06:00 PM EDT	Break	Break
06:00 PM - 06:15 PM EDT	Abstract	001 - Advancing Antigen-Specific T cell Therapy for Progressive Multifocal Leukoencephalopathy Sasha Gupta, MD
06:15 PM - 06:30 PM EDT	Abstract	002 - Anakinara to mitigate CAR T cell therapy associated toxicity Sudhakar Tummala, MD, FAAN
06:30 PM - 07:00 PM EDT	Speaker	Wrap up of Case and Panel Discussion

Faculty Disclosures
H. E. Hinson, MD, MCR, FAAN	Dr. Hinson has received personal compensation in the range of $0-$499 for serving as a Consultant for Rapid AI. Dr. Hinson has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Hinson has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology. Dr. Hinson has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association.
Antonio M. Omuro, MD, FAAN	Dr. Omuro has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Omuro has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ono Therapeutics. Dr. Omuro has received personal compensation in the range of $0-$499 for serving as a Consultant for Kiyatec. Dr. Omuro has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pyramid. Dr. Omuro has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Curevac. Dr. Omuro has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Current Opinion in Neurology. The institution of Dr. Omuro has received research support from NIH. The institution of Dr. Omuro has received research support from Agios. The institution of Dr. Omuro has received research support from Arcus Biosciences. The institution of Dr. Omuro has received research support from NIH. The institution of Dr. Omuro has received research support from NIH. The institution of Dr. Omuro has received research support from Denovo Biopharma.
Sasha Gupta, MD	Dr. Gupta has nothing to disclose.
	No disclosure on file
Sudhakar Tummala, MD, FAAN	Dr. Tummala has received personal compensation in the range of $500-$4,999 for serving as a Consultant for REVHEALTH LLC.
Irene Cortese, MD	Dr. Cortese has stock in Keires, AG. Dr. Cortese has stock in Nouscom, AG. Dr. Cortese has stock in PDC Pharma. Dr. Cortese has a non-compensated relationship as a scientific advisor with Cellevolve that is relevant to AAN interests or activities.
Michael R. Wilson, MD, FAAN	Dr. Wilson has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Delve Bio. Dr. Wilson has stock in Delve Bio. The institution of Dr. Wilson has received research support from Genentech / Roche. The institution of Dr. Wilson has received research support from NIH. The institution of Dr. Wilson has received research support from UCSF Weill Institute for Neurosciences. The institution of Dr. Wilson has received research support from Novartis. The institution of Dr. Wilson has received research support from National Multiple Sclerosis Society. The institution of Dr. Wilson has received research support from Fanconi Anemia Research Foundation. The institution of Dr. Wilson has received research support from Department of Defense. Dr. Wilson has received intellectual property interests from a discovery or technology relating to health care. Dr. Wilson has received intellectual property interests from a discovery or technology relating to health care. Dr. Wilson has received personal compensation in the range of $10,000-$49,999 for serving as a Expert Witness with US Dept of Justice.
Bianca Santomasso, MD	Dr. Santomasso has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen Pharmaceuticals. Dr. Santomasso has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol-Myers Squibb. Dr. Santomasso has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Kite/Gilead. Dr. Santomasso has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for In8bio. Dr. Santomasso has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Janssen Pharmaceuticals. Dr. Santomasso has received personal compensation in the range of $500-$4,999 for serving as a Committee Member Activity with National Comprehensive Cancer Network.