2022 Annual Meeting | C118 - Clinical Approach to Muscle Disease: Role of Antibodies, Muscle Imaging, and Genetic Testing

Date Wednesday 04/06/22

Time 07:00 AM - 09:00 AM PDT Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Seminar

Director(s) Margherita Milone, MD, FAAN

Topic(s) Neuromuscular and Clinical Neurophysiology (EMG)

Learning Objectives The discovery of new antibodies and genes causative of neuromuscular diseases, combined with easy access to novel testing, have accelerated the diagnosis of muscle diseases and impacted patient care. Serological markers have become crucial in characterizing immune-mediated myopathies, complementing muscle pathology. Muscle imaging has shown a growing role in the diagnostic process, phenotype characterization and clinical outcomes of muscle diseases. Genetic tests, essential for the diagnosis of inherited myopathies, are instrumental for patient care. Faculty will elucidate the state of the art of antibodies, imaging and genetic studies in the assessment and treatment of muscle diseases. Participants will recognize the clinical, serological, pathological, radiological and genetic heterogeneity of muscle diseases. Participants will become familiar with the myopathic phenotype, extramuscular manifestations and risk of cancer associated with specific myositis antibodies. Participants will appropriately utilize myositis-specific antibodies in clinical practice for both diagnostic and therapeutic purposes. Participants will become familiar with imaging studies that are commonly used in the diagnostic evaluation of muscle diseases. Participants will recognize imaging features that characterize acquired and inherited myopathies. Participants will become familiar with the spectrum of genetic tests and their limitations in the diagnosis of muscle diseases. Participants will recognize implications of genetic findings in patient care. This program compliments Clinical Approach to Muscle Disease: Inflammatory Myopathies and Muscle Pathology but covers independent topics.

CME Available 2.00 CME credits

Core Competencies Patient Care & Procedural Skills, Medical Knowledge, Practice-based Learning and Improvement

Program Level Intermediate

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Advanced Practice Provider, Neurohospitalist, Medical Student

Teaching Styles Case-based, Didactic

Program Materials Program Evaluations

Event Timeline
07:00 AM - 07:05 AM PDT	Introduction	Introduction to Muscle Diseases Margherita Milone, MD, FAAN
07:00 AM - 07:00 AM PDT	Speaker	Walk-in Slides Margherita Milone, MD, FAAN
07:05 AM - 07:40 AM PDT	Speaker	Role of Antibodies in Muscle Diseases Teerin Liewluck, MD, FAAN
07:40 AM - 08:15 AM PDT	Speaker	Role of Muscle Imaging in Muscle Diseases Doris G. Leung, MD
08:15 AM - 08:50 AM PDT	Speaker	Role of Genetic Testing in Muscle Diseases Margherita Milone, MD, FAAN
08:50 AM - 09:00 AM PDT	Q&A	Questions and Answers Margherita Milone, MD, FAAN, Teerin Liewluck, MD, FAAN, Doris G. Leung, MD

Faculty Disclosures
Margherita Milone, MD, FAAN	Dr. Milone has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx. Dr. Milone has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Neurology Genetics, AAN. The institution of Dr. Milone has received research support from Mayo Clinic, CCaTS-CBD. The institution of Dr. Milone has received research support from Mayo Clinic, SGP Award. The institution of Dr. Milone has received research support from MDA for Care Center grant. The institution of Dr. Milone has received research support from Regenerative medicine Minnesota.
Teerin Liewluck, MD, FAAN	Dr. Liewluck has nothing to disclose.
Doris G. Leung, MD	The institution of Dr. Leung has received research support from US Department of Defense. The institution of Dr. Leung has received research support from Fulcrum Therapeutics. The institution of Dr. Leung has received research support from ML Bio Solutions, Inc.. The institution of Dr. Leung has received research support from Sarepta Therapeutics. The institution of Dr. Leung has received research support from Cumberland Pharmaceuticals. The institution of Dr. Leung has received research support from FibroGen Inc.. The institution of Dr. Leung has received research support from Astellas Pharma. The institution of Dr. Leung has received research support from University of Kansas Medical Center Research Institute. The institution of Dr. Leung has received research support from Pfizer, Inc.. The institution of Dr. Leung has received research support from Genethon. The institution of Dr. Leung has received research support from Harmony Biosciences. The institution of Dr. Leung has received research support from Edgewise Therapeutics.