2023 Annual Meeting | N5 - Neuroscience in the Clinic: Can Sleep Prevent or Improve Neurologic Diseases?

Date Wednesday 04/26/23

Time 01:00 PM - 03:00 PM EST Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Neuroscience in the Clinic Session

Director(s) Temitayo Oyegbile-Chidi, MD, PhD, FAAN, Jeffrey Iliff, PhD

Topic(s) Sleep

Learning Objectives Participants will understand the emerging structure and function of the brain's glymphatic system as it has emerged from experimental studies over the past decade, and based on new studies carried out in human clinical populations recognize its potential implications in the development and treatment of sleep-related neurological disorders including Alzheimer's disease and traumatic brain injury.

CME Available 2.00 CME credits

Core Competencies Patient Care & Procedural Skills, Medical Knowledge

Program Level Introductory

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Non-neurologist, Advanced Practice Provider, Neurohospitalist, Medical Student

Teaching Styles Didactic

Event Timeline
01:00 PM - 01:10 PM EST	Introduction	Introduction and Case Presentation Temitayo Oyegbile-Chidi, MD, PhD, FAAN
01:10 PM - 01:20 PM EST	Speaker	A Primer on the Glymphatic System and Meningeal Lymphatic Drainage Jeffrey Iliff, PhD
01:20 PM - 01:40 PM EST	Speaker	Evidence for the Role of Glymphatic Impairment in Alzheimer's Disease Jeffrey Iliff, PhD
01:40 PM - 02:00 PM EST	Speaker	Cerebral Perivascular Spaces: Linking Mild Traumatic Brain Injury Exposure, Sleep Disruption, and Solute Clearance Impairment Juan Piantino, MD
02:00 PM - 02:20 PM EST	Speaker	Individuals with Comorbid Neurotrauma and REM Sleep Disorder Exhibit Greater Parkinsonism and 7T MRI Changes in N1 Nigrasome Compared to RBD Alone: Evidence For Glymphatic Dysfunction Miranda M. Lim, MD, PhD
02:20 PM - 02:30 PM EST	Abstract	001 - Sleep quality associated with neuroimaging measures of CSF flow in individuals with Parkinson's disease Tristan A. Ponzo
02:30 PM - 02:40 PM EST	Abstract	002 - Examining Glymphatic Flow after Traumatic Brain Injury Using Diffusion Tensor Imaging. Trevor Nelson
02:40 PM - 02:45 PM EST	Speaker	Case Wrap-up Temitayo Oyegbile-Chidi, MD, PhD, FAAN
02:45 PM - 03:00 PM EST	Discussion	Panel Discussion and Q&A Temitayo Oyegbile-Chidi, MD, PhD, FAAN, Jeffrey Iliff, PhD, Juan Piantino, MD, Miranda M. Lim, MD, PhD

Faculty Disclosures
Temitayo Oyegbile-Chidi, MD, PhD, FAAN	Dr. Oyegbile-Chidi has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for Spectrum. Dr. Oyegbile-Chidi has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for UC Regents. The institution of Dr. Oyegbile-Chidi has received research support from NIH.
Jeffrey Iliff, PhD	Dr. Iliff has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Gryphon Biosciences. Dr. Iliff has received personal compensation in the range of $100,000-$499,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Applied Cognition. Dr. Iliff has stock in Applied Cognition. Dr. Iliff has stock in Gryphon Biosciences. The institution of Dr. Iliff has received research support from US Department of Veteran's Affairs. The institution of Dr. Iliff has received research support from US Department of Defense. The institution of Dr. Iliff has received research support from National Institutes of Health. Dr. Iliff has received personal compensation in the range of $5,000-$9,999 for serving as a Programatic Committee Member with US Department of Defense.
	No disclosure on file
Tristan A. Ponzo	Mr. Ponzo has nothing to disclose.
Ciaran Considine, PhD	Dr. Considine has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for MDisrupt. Dr. Considine has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Park Dietz & Associates. The institution of Dr. Considine has received research support from NIH. The institution of Dr. Considine has received research support from DoD. The institution of Dr. Considine has received research support from Acadia Pharmaceuticals.
Daniel O. Claassen, MD, FAAN	Dr. Claassen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Teva Neuroscience. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Spark . The institution of Dr. Claassen has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant for Alterity. Dr. Claassen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Teva Neuroscience. Dr. Claassen has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for HD Insights. The institution of Dr. Claassen has received research support from NIH. The institution of Dr. Claassen has received research support from CHDI. The institution of Dr. Claassen has received research support from HDSA. The institution of Dr. Claassen has received research support from Department of Defense. The institution of Dr. Claassen has received research support from Griffin Family Foundation. The institution of Dr. Claassen has received research support from Neurocrine. The institution of Dr. Claassen has received research support from Vaccinex. The institution of Dr. Claassen has received research support from AbbVie. The institution of Dr. Claassen has received research support from CHDI. The institution of Dr. Claassen has received research support from Genentech/ Roche. The institution of Dr. Claassen has received research support from Prilenia. The institution of Dr. Claassen has received research support from Neurocrine/ HSG.
James J. Gugger, Jr., MD, PharmD	Dr. Gugger has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Ceribell. The institution of Dr. Gugger has received research support from American Epilepsy Society.
Danielle Sandsmark, MD	The institution of Dr. Sandsmark has received research support from NINDS.
Andrea L. Schneider, MD, PhD	Dr. Schneider has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AAN - Neurology.
Ramon R. Diaz-Arrastia, MD, PhD, FAAN	Dr. Diaz-Arrastia has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Ischemix, Inc. Dr. Diaz-Arrastia has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Pinteon Therapeutics. Dr. Diaz-Arrastia has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BrainBox, LLC. Dr. Diaz-Arrastia has received stock or an ownership interest from BrainBox, LLC. Dr. Diaz-Arrastia has received stock or an ownership interest from NovaSignal . Dr. Diaz-Arrastia has received stock or an ownership interest from Nia Therpeutics. The institution of Dr. Diaz-Arrastia has received research support from National Institutes of Health. The institution of Dr. Diaz-Arrastia has received research support from Department of Defense.
Trevor Nelson	Mr. Nelson has nothing to disclose.
Juan Piantino, MD	Dr. Piantino has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Applied Cognition.
Miranda M. Lim, MD, PhD	Dr. Lim has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Applied Cognition. Dr. Lim has stock in Applied Cognition. The institution of Dr. Lim has received research support from NIH. The institution of Dr. Lim has received research support from VA. The institution of Dr. Lim has received research support from Department of Defense. The institution of Dr. Lim has received research support from National Science Foundation. Dr. Lim has received publishing royalties from a publication relating to health care.