2023 Annual Meeting | S39 - Neurobiology of Dementia

Date Wednesday 04/26/23

Time 03:30 PM - 05:30 PM EST Add To Calendar

Session Format This program will be presented both in-person and online

On Demand This program will be available in the meeting's On Demand product.

Event Type Scientific Platform Session

Moderator(s) David Irwin, MD, Kamalini G. Ranasinghe, MD, PhD

Topic(s) Aging, Dementia, and Behavioral Neurology

Learning Objectives A group of abstracts covering a similar topic presented in an oral format. Presentations are eight minutes in length with four minutes for question and answer with the author.

CME Available 2.00 CME credits

Recommended Audience Fellow, Resident, General Neurologist, Specialist Neurologist, Non-neurologist, Advanced Practice Provider, Neurohospitalist, Medical Student

Teaching Styles Didactic

Event Timeline
03:30 PM - 03:42 PM EST	Abstract	001 - Diagnosis of Alzheimer’s Disease and Tauopathies on Whole Slide Images using Deep Learning Algorithm Shunsuke Koga, MD, PhD
03:42 PM - 03:54 PM EST	Abstract	002 - Prediction of Regional Tau Spread Using Individualized Tau Epicenters and Structural Connectomes Christopher A. Brown, MD, PhD
04:06 PM - 04:18 PM EST	Abstract	004 - Effects of APOE4 and education on the clinical onset of autosomal dominant Alzheimer's disease due to the PSEN1 E280A mutation Nicholas G. Barksdale, BA
04:18 PM - 04:30 PM EST	Abstract	005 - Amygdala Atrophy as an Early Manifestation of Alzheimer’s Disease Lina Al-Ani
04:30 PM - 04:42 PM EST	Abstract	006 - Characterization of the Monoamine Oxidase-B (MAO-B) Expression in Postmortem Normal and Alzheimer’s Disease Brains Methasit Jaisa-aad, MD
04:42 PM - 04:54 PM EST	Abstract	007 - Clinical and genetic characteristics of patients with very early onset frontotemporal dementia Adit Friedberg, MD
04:54 PM - 05:06 PM EST	Abstract	008 - Associations between neuropsychiatric symptoms, pathology, and survival in an autopsy-confirmed cohorts of Alzheimer’s disease, Alzheimer’s disease with Lewy bodies and Dementia with Lewy bodies Neha Shakir
05:06 PM - 05:18 PM EST	Abstract	009 - Association of Traumatic Brain Injury, Mild Cognitive Impairment and Dementia in the Framingham Heart Study’s Original Cohort Shruti S. Durape, MBBS, MPH
05:18 PM - 05:30 PM EST	Abstract	010 - MCI patients with COVID-19 Have Increased Progression to Dementia at 18 months Calin I. Prodan, MD

Faculty Disclosures
	No disclosure on file
Geidy Serrano	No disclosure on file
Dennis W. Dickson, MD	Dr. Dickson has nothing to disclose.
Jeremy J. Pruzin, MD	Dr. Pruzin has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Pruzin has received personal compensation in the range of $500-$4,999 for serving as a Consultant for MedNet. Dr. Pruzin has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Synapticure. The institution of Dr. Pruzin has received research support from Alzheimer's Association. The institution of Dr. Pruzin has received research support from NIA.
Bruce L. Miller, MD, FAAN	Dr. Miller has nothing to disclose.
Claire E. Delpirou Nouh, MD	Dr. Delpirou Nouh has nothing to disclose.
Parichita Choudhury, MD	The institution of Dr. Choudhury has received research support from Lewy Body Dementia Association. The institution of Dr. Choudhury has received research support from Arizona Alzheimer's Consortium.
Calin I. Prodan, MD	The institution of Dr. Prodan has received research support from US Department of Veterans Affairs (Merit award CX000340).
Nan Zhang	No disclosure on file
Chao Xu	No disclosure on file
Jennifer S. Yokoyama, PhD	The institution of Dr. Yokoyama has received research support from NIH. The institution of Dr. Yokoyama has received research support from Alzheimer's Association . The institution of Dr. Yokoyama has received research support from Mary Oakley Foundation. The institution of Dr. Yokoyama has received research support from Alector. The institution of Dr. Yokoyama has received research support from Transposon. The institution of Dr. Yokoyama has received research support from Rainwater Charitable Foundation.
Methasit Jaisa-aad, MD	Dr. Jaisa-aad has nothing to disclose.
John A. Detre, MD	Dr. Detre has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Hura Imaging. The institution of Dr. Detre has received research support from NIH. Dr. Detre has received personal compensation in the range of $500-$4,999 for serving as a grant proposal reviewer with NIH, VA, European Science Foundation,Deutsche Forschungsgemeinschaft.
Nicholas G. Barksdale, BA	Mr. Barksdale has nothing to disclose.
Alice Tao	Ms. Tao has nothing to disclose.
Lina Al-Ani	Miss Al-Ani has nothing to disclose.
Yorghos Tripodis	No disclosure on file
Angelia Kirkpatrick	Angelia Kirkpatrick has nothing to disclose.
Michael Alosco, PhD	The institution of Michael Alosco, PHD has received research support from NIH.
Shunsuke Koga, MD, PhD	Dr. Koga has nothing to disclose.
Neha Shakir	Miss Shakir has nothing to disclose.
Daniel H. Geschwind, MD, PhD	Dr. Geschwind has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Ovid Therapeutics, Inc.. Dr. Geschwind has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for AcuraStem, Inc.. Dr. Geschwind has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Axial Biotherapeutics, Inc.. Dr. Geschwind has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Falcon Computing. Dr. Geschwind has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier-Biological Psychiatry. Dr. Geschwind has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NYAS. Dr. Geschwind has received personal compensation in the range of $50,000-$99,999 for serving as an Expert Witness for Covington& Burling LLP. Dr. Geschwind has stock in none related to talk. The institution of Dr. Geschwind has received research support from CurePSP. The institution of Dr. Geschwind has received research support from NINDS. The institution of Dr. Geschwind has received research support from Rainwater Charitable Foundation. The institution of Dr. Geschwind has received research support from NIMH. The institution of Dr. Geschwind has received research support from NINDS. The institution of Dr. Geschwind has received research support from NIH. The institution of Dr. Geschwind has received research support from The Simons Foundation. The institution of Dr. Geschwind has received research support from NIH/NIMH. The institution of Dr. Geschwind has received research support from Adelson Medical Research Foundation. The institution of Dr. Geschwind has received research support from NINDS. The institution of Dr. Geschwind has received research support from NIMH. The institution of Dr. Geschwind has received research support from NINDS/NIA. The institution of Dr. Geschwind has received research support from NIH/NIMH. The institution of Dr. Geschwind has received research support from Adelson Medical Research Foundation. The institution of Dr. Geschwind has received research support from NIH/NINDS. The institution of Dr. Geschwind has received research support from NIH/NIMH. The institution of Dr. Geschwind has received research support from NIH/NIMH. The institution of Dr. Geschwind has received research support from Adelson Medical Research Foundation. The institution of Dr. Geschwind has received research support from U of Virginia and NIH/NIMH. The institution of Dr. Geschwind has received research support from NIH. The institution of Dr. Geschwind has received research support from NIH/NHGRI. The institution of Dr. Geschwind has received research support from NIH/NIMH. Dr. Geschwind has received intellectual property interests from a discovery or technology relating to health care. Dr. Geschwind has received intellectual property interests from a discovery or technology relating to health care. Dr. Geschwind has received intellectual property interests from a discovery or technology relating to health care. Dr. Geschwind has received intellectual property interests from a discovery or technology relating to health care.
Andriy Yabluchanskiy	No disclosure on file
Jesse B. Mez, MD	The institution of Dr. Mez has received research support from NIH, DOD.
William Seeley, MD	Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GLG Council. Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint Global Consulting. Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BridgeBio. Dr. Seeley has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Seeley has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lyterian Therapeutics. The institution of Dr. Seeley has received research support from NIH. The institution of Dr. Seeley has received research support from Rainwater Charitable Foundation. The institution of Dr. Seeley has received research support from Bluefield Project to Cure FTD. The institution of Dr. Seeley has received research support from Chan-Zuckerberg Initiative.
Alberto Serrano-Pozo, MD, PhD	Dr. Serrano-Pozo has received research support from NIH/NIA. Dr. Serrano-Pozo has received research support from Alzheimer's Association. Dr. Serrano-Pozo has received research support from The Jack Satter Foundation. Dr. Serrano-Pozo has received research support from The Karen Toffler Charitable Trust. Dr. Serrano-Pozo has received research support from Ionis Pharmaceuticals, Inc. Dr. Serrano-Pozo has received research support from AbbVie, Inc..
Tharick A. Pascoal, Sr., MD, PhD	No disclosure on file
David F. Aguillon, Sr.	No disclosure on file
Christopher A. Brown, MD, PhD	The institution of Dr. Brown has received research support from National Institute of Health.
Farhat Husain, MD	Dr. Husain has nothing to disclose.
Corey McMillan, PhD	Dr. McMillan has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. The institution of Dr. McMillan has received research support from Biogen. The institution of Dr. McMillan has received research support from NIH.
Gloria Chiang	No disclosure on file
Kristen Dams-O'Connor, PhD	Dr. Dams-O'Connor has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for Various law firms. The institution of Dr. Dams-O'Connor has received research support from NIH. The institution of Dr. Dams-O'Connor has received research support from Department of Defense. The institution of Dr. Dams-O'Connor has received research support from National Institute on Disability Independent Living and Rehabilitation Research. The institution of Dr. Dams-O'Connor has received research support from Patient Reported Outcomes Research Institute.
Rhoda Au, PhD	Dr. Au has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Au has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Merck. Dr. Au has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Au has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NovoNordisk. Dr. Au has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for GSK. Dr. Au has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai. Dr. Au has received publishing royalties from a publication relating to health care. Dr. Au has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant with Davos Alzheimer's Collaborative. Dr. Au has received personal compensation in the range of $50,000-$99,999 for serving as a Consultant with High Lantern.
David A. Wolk, MD, FAAN	Dr. Wolk has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Wolk has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Functional Neuromodulation. Dr. Wolk has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for GSK. The institution of Dr. Wolk has received research support from Biogen. Dr. Wolk has received publishing royalties from a publication relating to health care. Dr. Wolk has received personal compensation in the range of $5,000-$9,999 for serving as a CME speaker with Eli Lilly.
Shruti S. Durape, MBBS, MPH	Dr. Durape has nothing to disclose.
Makoto Ishii, MD, PhD	Dr. Ishii has stock in Regeneron Pharmaceuticals. The institution of Dr. Ishii has received research support from NIH. The institution of Dr. Ishii has received research support from BrightFocus Foundation. The institution of Dr. Ishii has received research support from Alzheimer's Association. Dr. Ishii has received personal compensation in the range of $0-$499 for serving as a Author/Contributor with Relias Media.
Kenneth S. Kosik, MD	Dr. Kosik has received personal compensation in the range of $50,000-$99,999 for serving as an officer or member of the Board of Directors for Rainwater Foundation. The institution of Dr. Kosik has received research support from National Institute of Health. The institution of Dr. Kosik has received research support from Hillblom Foundation. The institution of Dr. Kosik has received research support from Adelson Medical Foundation. The institution of Dr. Kosik has received research support from Alzheimer Association/Rainwater Foundation. The institution of Dr. Kosik has received research support from Thome Memorial FOundation.
Ilya Nasrallah, MD, PhD	Dr. Nasrallah has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Nasrallah has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Nasrallah has received personal compensation in the range of $0-$499 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer. Dr. Nasrallah has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Cassiday Schade LLP. The institution of Dr. Nasrallah has received research support from NIH. The institution of Dr. Nasrallah has received research support from ASNR.
Yasuomi Ouchi, MD, PhD	The institution of Prof. Ouchi has received research support from Sumitomo Pharma Co., Ltd.
Cecilia Tremblay	No disclosure on file
Charles H. Adler, MD, PhD, FAAN	Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Avion. Dr. Adler has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for CND Life Sci. Dr. Adler has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Jazz. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Precon. Dr. Adler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. The institution of Dr. Adler has received research support from NIH. The institution of Dr. Adler has received research support from Michael J. Fox Foundation. The institution of Dr. Adler has received research support from Arizona Biomedical Research Commission. Dr. Adler has received publishing royalties from a publication relating to health care.
Pedro Rosa Neto, MD, PhD	The institution of Dr. Rosa Neto has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novo Nordisk.
Hiroaki Sekiya, MD, PhD	Dr. Sekiya has nothing to disclose.
Douglas I. Katz, MD, FAAN	Dr. Katz has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Law firms. The institution of Dr. Katz has received research support from NINDS/NIH. Dr. Katz has received publishing royalties from a publication relating to health care.
Christine Belden	No disclosure on file
Francisco J. Lopera Restrepo, MD, PhD	No disclosure on file
Eric M. Reiman, MD	Dr. Reiman has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Denali, Green Valley, Zinfandel, and Takeda. Dr. Reiman has received stock or an ownership interest from Alkahest, Alzheon, Aural Analytics, Denali, and United Neuroscience.. Dr. Reiman has received intellectual property interests from a discovery or technology relating to health care. Dr. Reiman has received personal compensation in the range of $500-$4,999 for serving as a Member, National Advisory Council on Aging (NACA) with NIA.
Yakeel Quiroz, PhD	Dr. Quiroz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Quiroz has received intellectual property interests from a discovery or technology relating to health care.
William J. Therriault	Mr. Therriault has nothing to disclose.
Thomas Beach	Thomas Beach has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vivid Genomics. Thomas Beach has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche Diagnostics. The institution of Thomas Beach has received research support from National Institutes of Health. The institution of Thomas Beach has received research support from Michael J Fox Foundation . The institution of Thomas Beach has received research support from State of Arizona.
Bradley T. Hyman, MD, PhD	An immediate family member of Dr. Hyman has received personal compensation for serving as an employee of novartis. Dr. Hyman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for dewpoint. Dr. Hyman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for abbvie. Dr. Hyman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Arvinas. Dr. Hyman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for avrobio. Dr. Hyman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Hyman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Dept of Justice. Dr. Hyman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cell Signalling. Dr. Hyman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Sangamo. Dr. Hyman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for sanofi. Dr. Hyman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for vigil. Dr. Hyman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for voyager. Dr. Hyman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for biogen. Dr. Hyman has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for dept of justice. Dr. Hyman has stock in dewpoint. The institution of Dr. Hyman has received research support from nih. The institution of Dr. Hyman has received research support from JPB. The institution of Dr. Hyman has received research support from Cure Alz Fund. The institution of Dr. Hyman has received research support from Tau consortium. The institution of Dr. Hyman has received research support from abbvie. The institution of Dr. Hyman has received research support from BMS.
Silvia J. Rios Romenets, MD	Dr. Rios Romenets has nothing to disclose.
Hyun-Sik Yang, MD	The institution of Dr. Yang has received research support from National Institutes of Health. Dr. Yang has received personal compensation in the range of $500-$4,999 for serving as a study section member with National Institutes of Health.
Jim Scott	No disclosure on file
Adit Friedberg, MD	The institution of Dr. Friedberg has received research support from The Larry L. Hillblom Foundation . The institution of Dr. Friedberg has received research support from The Global Brain Health Institute.
Alireza Atri, MD, PhD	Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Prothena. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eisai. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novo Nordisk. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lundbeck. Dr. Atri has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novo Nordisk. Dr. Atri has received personal compensation in the range of $50,000-$99,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche/Genentech. Dr. Atri has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Lunbeck. The institution of Dr. Atri has received research support from National Institute of Aging (NIA). The institution of Dr. Atri has received research support from AZ Department of Health Services. The institution of Dr. Atri has received research support from Gates Ventures. The institution of Dr. Atri has received research support from Multiple companies, universities & consortia for contracted clinical trials to institution. The institution of Dr. Atri has received research support from Washington University in St. Louis. The institution of Dr. Atri has received research support from Foundation for NIH. The institution of Dr. Atri has received research support from ACTC/NIH. Dr. Atri has received publishing royalties from a publication relating to health care.
Andrea Vincent	No disclosure on file
Kurtis Chien-Young	Mr. Chien-Young has received research support from the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number T35HL139444.
David Irwin, MD	The institution of Dr. Irwin has received research support from NIH. The institution of Dr. Irwin has received research support from Prevail. The institution of Dr. Irwin has received research support from Passage Bio. The institution of Dr. Irwin has received research support from Alector. The institution of Dr. Irwin has received research support from Transposon. The institution of Dr. Irwin has received research support from Denali.
Kamalini G. Ranasinghe, MD, PhD	Dr. Ranasinghe has nothing to disclose.